dc.contributor.author | Hovland, Anders | |
dc.contributor.author | Nestvold, Torunn Kristin | |
dc.contributor.author | Bohov, Pavol | |
dc.contributor.author | Trøseid, Marius | |
dc.contributor.author | Aukrust, Pål | |
dc.contributor.author | Berge, Rolf Kristian | |
dc.contributor.author | Nielsen, Erik Waage | |
dc.contributor.author | Retterstøl, Kjetil | |
dc.contributor.author | Lappegård, Knut Tore | |
dc.date.accessioned | 2018-04-10T09:32:12Z | |
dc.date.available | 2018-04-10T09:32:12Z | |
dc.date.issued | 2017-10-25 | |
dc.description.abstract | Background: <br>
Obesity is a global pandemic leading to increased mortality and increased risk of
cardiovascular disease. Bariatric surgery is an established treatment of obesity leading
to weight loss and reduction of mortality. To further elucidate how bariatric surgery
improves metabolic control, we explored the fatty acid (FA) profiles in morbidly
obese subjects treated with lifestyle intervention and subsequent bariatric surgery.
<br>Methods:<br>
The intervention group consisted of 34 morbidly obese patients scheduled for bariatric
surgery and the control group of 17 non-obese patients scheduled for elective
laparoscopic procedures. The intervention group had to undergo lifestyle changes
preoperatively. Fasting blood samples were drawn at admission, after lifestyle
intervention and one year after bariatric surgery.
<br>Results: <br>
At admission, the morbidly obese patients had significantly higher levels of
monounsaturated FAs (MUFAs) and lower levels of n-6 polyunsaturated FAs
(PUFAs) and n-3 PUFAs than healthy controls (all p-values<0.05). In the intervention
group, there was a significantly lower level of total FAs after lifestyle intervention,
and from admission to one year after surgical intervention (both, p<0.05), primarily
reflecting a lower proportion of saturated FAs (SFAs). Following bariatric surgery,
but not after lifestyle changes, there was an increase in the proportion of n-3 PUFA
(p<0.05) reaching levels not significantly different from healthy controls.<br>
Conclusions: <br>
Our findings suggest that a reduced proportion of the proposed anti-atherogenic n-3
PUFAs characterizes morbidly obese individuals, and that this FA profile is reversed
by bariatric surgery, but not by lifestyle intervention. | en_US |
dc.description | This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Clinical and Laboratory Investigation on October 25th 2017, available online: <a href=http://doi.org/10.1080/00365513.2017.1393691> http://doi.org/10.1080/00365513.2017.1393691 </a> | en_US |
dc.identifier.citation | Hovland, A., Nestvold, T. K., Bohov, P., Trøseid, M., Aukrust, P., Berge, R. K., Nielsen, E. W. ... & Lappegård, K. T. (2017). Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals. Scandinavian Journal of Clinical and Laboratory Investigation, 77(8), 628-633. http://doi.org/10.1080/00365513.2017.1393691 | en_US |
dc.identifier.cristinID | FRIDAID 1528033 | |
dc.identifier.doi | 10.1080/00365513.2017.1393691 | |
dc.identifier.issn | 0036-5513 | |
dc.identifier.issn | 1502-7686 | |
dc.identifier.uri | https://hdl.handle.net/10037/12509 | |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.relation.journal | Scandinavian Journal of Clinical and Laboratory Investigation | |
dc.rights.accessRights | openAccess | en_US |
dc.subject | VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773 | en_US |
dc.subject | VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gastroenterology: 773 | en_US |
dc.title | Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |