In this study, gel phase (DPPC) and liquid phase (soy PC) neutral liposomes were coated with hydrophobically modified hydroxyethyl cellulose (HM-HEC). The chain lengths of the hydrophobic moieties of HM-HEC were C8 and C16. The influence of the hydrophobic chain length of the polymer coating on the release of a fluorescence marker was studied at both 35 °C and 4 °C. I addition the size, zeta ...

Conotoxins are diverse and well-studied, and is therefore suited as a model to develop a general method for analyzing disulfide-rich peptides. To investigate the folding of both commercially available and self-synthesized Conotoxins, an UHPLC-MS/MS method was developed where one disulfide-bridge was reduced at the time and alkylated with different maleimides. The results from the UHPLC-MS/MS method ...

Damage to the healthy skin barrier leads to a rapid and complex process of wound healing to restore the skins normal function and structure. The presence of bacteria in wounds such as pressure ulcers and diabetic foot ulcers impairs the healing process and leads to increased patient morbidity and mortality as well as reduced patient life quality. Bacteria growing in the wound environment form biofilm, ...

A novel method was developed for UPLC-MS analysis of phospholipids in complex lipid samples. The methods developed allowed for identification and structural elucidation of different PL species and by utilizing MSE technology, rapid qualitative analyses of complex lipid samples were made possible. By using UPLC-MS it was confirmed that a high proportion of the total content of commercial marine oils ...

Seksuelt overførbare infeksjoner og andre gynekologiske sykdommer vil man helst behandle lokalt. Hos kvinner er vaginal administrasjon fordelaktig for behandling av nettopp slike sykdommer. Det er flere utfordringer som må overvinnes når farmasøytiske formuleringer til vaginal administrasjon skal utvikles; vagina har en evne til å rense seg selv, det skjer hele tiden fysiologiske forandringer i ...