English
norskInstitutt for farmasi: Nye registreringer
Viser treff 641-660 av 706
-
Development of liposomal curcumin for vaginal drug delivery
(Master thesis; Mastergradsoppgave, 2010-06-16)Curcumin (I), demethoxy curcumin (II) and bisdemethoxy curcumin (III) are commonly called curcuminoids, and derived products from the spice, turmeric. It has reported numerous of therapeutic activities including, anti-inflammatory, and anticancer properties. The aim of the current study was to develop a formulation which can overcome the limitation of curcumin being so poorly soluble in aqueous ... -
Hydrogels of natural origin in wound healing : formulation devolopment
(Master thesis; Mastergradsoppgave, 2010-05-20)Hydrogels made of chitosan has a well-established place in drug delivery for the skin. Our particular interest were hydrogels for wound healing. Hydrogels from low, medium and high molecular weight were prepared in different concentrations for texture and release characterization incorporating liposomes and chloramphenicol as a model drug. A method for comparing viscosity between gels was established ... -
Finnes det et potensiale for at apotekfarmasøyter kan bidra til bedre kunnskap om statiner - og derved bidra til en større grad av måloppnåelse med forebyggende statinbehandling?
(Master thesis; Mastergradsoppgave, 2010-05-20)Masteroppgaven har som mål å kartlegge kunnskap om kolesterolsenkende behandling (statiner)blant kundene på apotek. Oppgaven er gjennomført på tre sykehusapotek: i Tromsø, Bodø og Trondheim. -
Screening for antibacterial and antifungal activities in marine benthic invertebrates from northern Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-06-18)Benthic marine invertebrates collected from sub-Arctic regions of northern Norway, were found to be a promising source of novel bioactive compounds against human and fish pathogenic bacteria and fungi. Lyophilized material from seven species of ascidians, six sponges and one soft alcyonid coral were extracted with 60% acidified acetonitrile (ACN). After separation into an ACN-rich phase (ACN extract) ... -
Dosing omissions among medical patients in a hospital electronic prescribing and medicine administration (HEPMA) system
(Master thesis; Mastergradsoppgave, 2009-05)Background Omitted doses are among the most common errors of medication errors in hospital. It is a need to identify the frequency of omitted doses and reasons for these to try to prevent them in the future. It is important to ensure all medication is available on the ward when needed and this can be evaluated by looking at different medicines management systems. Aim and objectives To identify ... -
Continuity of care during hospital stay: A review and evaluation of medicines reconciliation on admission
(Master thesis; Mastergradsoppgave, 2009-05)Background: Errors in the stage of prescribing make approximately 16 % of all medication errors. There is a need to identify the frequency of this, and also to assess the impact of contributions by pharmacists to the patient’s care. Aim and objectives: To characterise the nature and frequency of medicines errors in patients during the process of admission to hospital, and also to evaluate ... -
Clinical audit of dosing omissions among surgical patients in a hospital electronic prescribing and medicine administration(HEPMA) system
(Master thesis; Mastergradsoppgave, 2009-05)Abstract Background: Medication errors are a national concern, and even small changes can make a real difference in reducing harm to patients. Dose omissions are one of the medication errors causing harm, and it is a recommendation for NHS organisations to periodically audit all omissions to help target where improvements can be performed to prevent these errors. Aim and objectives: The aim ... -
En legemiddeløkonomisk analyse av acetylsalisylsyre som primærprofylakse mot hjerte- og karsykdommer
(Master thesis; Mastergradsoppgave, 2009-05)Verdens helseorganisasjon (WHO) anbefaler primærforebyggende behandling med acetylsalisylsyre (ASA) hos pasienter med forhøyet risiko for utvikling av hjerte- og karsykdom. Per i dag ytes det ikke generell refusjon til forebyggende behandling med lavdosert ASA. Det var behov for å kartlegge hvorvidt primærforebygging av kardiovaskulære sykdommer med ASA viste seg å være en god utnyttelse av samfunnets ... -
Utviklingen av en metode for påvisning av selektive serotonin reopptakshemmere i sjøvannsprøver med stort volum
(Master thesis; Mastergradsoppgave, 2009-06)Til påvisning av selektive serotonin reopptakshemmere (SSRI) i sjøvann har det tidligere blitt benyttet ulike teknikker; væske-væske mikroekstraksjon (LPME) og tradisjonell fast faseekstraksjon (SPE). Disse metodene har vært begrenset av henholdsvis prøvevolum og tidkrevende ekstraksjon. Det har derfor vært et mål å utvikle en SPE-metode som er rask og effektiv, og som samtidig ved hjelp av store ... -
Utvikling av en LC-MS/MS metode for kvantitativ analyse av klopidogrel og klopidogrelmetabolitter i serum
(Master thesis; Mastergradsoppgave, 2009-05-20)Legemidlet Plavix® (klopidogrel) er en blodplatehemmer som brukes i kombinasjon med acetylsalisylsyre (ASA) som profylakse etter stentimplantasjon for å hindre dannelsen av stenttrombose. Klopidogrel er et prodrug og krever hepatisk biotransformasjon for å utøve sin antiaggregerende effekt. Bruken av klopidogrel har økt betraktelig de siste årene. I 2004 ble klopidogrel brukt av 17973 individer i ... -
Analysis of selected benzodiazepines in the environment by HF-LPME and LC-MS/MS
(Master thesis; Mastergradsoppgave, 2009-05)Industrial chemicals, pesticides and other similar compounds are all known to be a burden for the environment. In high concentrations they can all affect the biological environment in a manner that is dangerous for organisms. The presence of pharmaceuticals and personal care products (PPCPs) in the environment are of great interest regarding to their potential toxicity. Pharmaceuticals and PPCPs are ... -
Organiske utlekkstoffer fra resinbaserte tannrestaureringsmaterialer: utvikling av analysemetode ved bruk av kombinert gasskromatografi-massespektrometri og kjemisk ionisasjon
(Master thesis; Mastergradsoppgave, 2009-06-16)Polymerbaserte resiner har i dag erstattet amalgam som tannfyllingsmateriale. Kvikksølv, en hovedkomponent i amalgam, har negative miljøeffekter og har antatte skadelige effekter på pasienter og tannlegepersonell. Norge innførte 1. januar 2008 forbud mot all bruk av kvikksølv i produkter. Samtidig har studier vist at innholdsstoffer og nedbrytingsprodukter kan lekke fra de polymerbaserte ... -
A study of patient pharmaceutical care needs assessment in chronic obstructive pulmonary disease; as an example of a multidisciplinary intervention to reduce hospital re-admission in long term conditions
(Master thesis; Mastergradsoppgave, 2009-05-20)Introduction — The aim of Edinburgh Improved Anticipatory Care and Treatment (IMPACT) service is to reduce admissions and re-admissions to hospital for people with LTCs. The service consists of nurse case managers co-ordinating patients’ care, including reviewing medication. As a pilot project, an arrangement was made to refer such patients to a team of primary care pharmacists for clinical medication ... -
Quantification of absolute and relative fitness in Acinetobacter baylyi under varying growth conditions
(Master thesis; Mastergradsoppgave, 2009-08-28)Natural transformation is one of three ways for bacteria to acquire genetic material (DNA) horizontally. Several hypotheses exist for why some bacteria have this ability to take up DNA, and what the incoming DNA is used for. These include use of DNA for recombination, repair or as nutrients. This master study focuses on the “food hypothesis”. This hypothesis implies that the exogenous DNA is ... -
Kvantitative analyser av gentamicin og tobramycin i blod med LC-MS/MS
(Master thesis; Mastergradsoppgave, 2009-05-20)Etter den første dosen, blir dosering av aminoglykosider styrt av hyppige målinger av serumkonsentrasjonen. Målingene blir gjort ved hjelp av en immunoassay basert metode. Denne metoden krever relativt store prøvevolum, og målingene kan påvirkes av samtidig behandling med TPN. Målsetningen var å utvikle en LC- MS/MS basert metode for å kvantifisere tobramycin og gentamicin i små prøvevolum. Det ... -
Modifier gene polymorphisms and influence on disease expression in HNPCC
(Master thesis; Mastergradsoppgave, 2009-05-20)Background Hereditary non-polyposis colorectal cancer(HNPCC) is an autosomal dominantly inherited predisposition to a variety of epithelial malignancies most notable colorectal and endometrial cancer. Unlike other genetic predispositions to colorectal cancer HNPCC does not present with a premalignant phenotype, which as such makes it difficult to predict when or if an affected person will present ... -
Modifier gene polymorphisms and influence on disease expression in FAP
(Master thesis; Mastergradsoppgave, 2009-05-20)Background: Familial adenomatous polyposis (FAP) is a hereditary autosomal dominant condition characterized by the appearance of hundreds to thousands of adenomatous polyps throughout the colon and rectum. If the condition is left untreated it will ultimately develop into colorectal cancer. Most of the articles available today concerning FAP focus on the adenomatous polyposis coli gene as this gene ... -
Investigations of binding mode for the cyclopentapeptide CXCR4 antagonist FC131 by induced fit docking
(Master thesis; Mastergradsoppgave, 2009-06-12)The GPCR CXCR4 is a chemokine receptor that by activation of its natural ligand SDF-1α is involved in the pathology of several diseases like cancer metastasis, leukemia cell progression and rheumatoid arthritis. The finding that CXCR4 plays a critical role for HIV-1 entry into T cells prompts additional motivation for the design of CXCR4 inhibitor. The establishment of the possible binding mode(s) ... -
Active loading of gemcitabine into liposomes
(Master thesis; Mastergradsoppgave, 2009-05)Gemcitabine is a well established anticancer compound, and is in use today against several types of cancers. Gemcitabine has a short half life. Formulations of gemcitabine containing liposomes could extend it's half life, thereby maybe improving its effectiveness. Also, liposomes in the smaller size range have an advantage when it comes to treating cancer. They accumulate at the site of the tumor, ... -
En legemiddeløkonomisk analyse av antibiotikabruk ved invasive mrsa-infeksjoner
(Master thesis; Mastergradsoppgave, 2009-05-20)Invasiv MRSA-infeksjon initieres på sykehus og behandles med vancomycin eller linezolid. Vancomycin mot annen infeksjon enn i tarmen kan bare tas som infusjon og administreres derfor vanligvis kun på sykehuset. Linezolid kan tas som infusjon eller tabletter. Så lenge behandlingen foregår på sykehuset dekker sykehuset kostnadene til begge legemidler. Både vancomycin og linezolid har refusjon gjennom ...
