| dc.contributor.advisor | Ghosh, Abhik | |
| dc.contributor.author | Thomassen, Ivar Kristian | |
| dc.date.accessioned | 2018-09-06T12:18:26Z | |
| dc.date.available | 2018-09-06T12:18:26Z | |
| dc.date.issued | 2018-09-28 | |
| dc.description.abstract | Iodinated aromatics are excellent starting materials for further elaboration via transition-metal-catalyzed cross-coupling reactions. Considering the diverse applications of porphyrins and corroles - as photosensitizers in photodynamic therapy, dye sensitized solar cells, near-infrared dyes, gas sensors, nonlinear optical materials, and catalysts - the synthetic potential of β-polyiodinated or octaiodinated porphyrins and corroles may be considerable. As part of my doctoral studies, I have synthesized and structurally characterized the first examples of both β-octaiodinated porphyrins and β-octaiodinated corroles. Furthermore, a single-crystal X-ray structure of free base β-octaiodoporphyrin provided an example of a cis porphyrin tautomer, the long hypothesized intermediate of porphyrin NH tautomerism. | en_US |
| dc.description.doctoraltype | ph.d. | en_US |
| dc.description.popularabstract | Porphyrins are a class of ring-shaped molecules capable of binding a metal ion at their center, which are perhaps most familiar in the form of the red color (hemoglobin) of blood and the green color (chlorophyll) of plants. They serve an incredible number of biological functions and are often referred to as the colors of life. Chemists are adept at making synthetic analogues of these molecules, which can also be very useful in a wide-range of applications such as cancer treatment, the construction of solar cells, and industrial catalysis. This is what I have worked on. The synthetic porphyrins that I have made should act as precursors to a variety of reagents for cancer imaging and therapy. In a second development, I have studied in depth the position and movement of the hydrogen atoms in a metal-free porphyrin. This study should allow a deeper understanding of how porphyrins incorporate a metal such as iron when forming hemoglobin. | en_US |
| dc.description.sponsorship | I wish to thank the Research Council of Norway’s FRIPRO program for supporting me and giving me the freedom to pursue my own ideas. | en_US |
| dc.description | <p>Paper A and paper B with supporting information are not available in Munin. <p>
<p>Paper A: Thomassen, I.K., Vazquez-Lima, H., Gagnon, K.J. & Ghosh, A. (2015). Octaiodoporphyrin. Available in <a href=https://doi.org/10.1021/acs.inorgchem.5b02127>Inorganic Chemistry, 54(23), 11493-11497.</a><p>
<p>Paper B: Thomassen, I.K., McCormick, L.J & Ghosh, A. (2018). Molecular Structure of a β-Octaiodo-meso-tetraarylporphyrin. A Rational Route to cis Porphyrin Tautomers? (Manuscript). Published version, with altered title, available in <a href=https://doi.org/10.1021/acs.cgd.8b00629>Crystal Growth & Design, 18(8), 4257-4259.</a><p> | en_US |
| dc.identifier.isbn | 978-82-8236-314-3 (trykt) og 978-82-8236-315-0 (pdf) | |
| dc.identifier.uri | https://hdl.handle.net/10037/13701 | |
| dc.language.iso | eng | en_US |
| dc.publisher | UiT Norges arktiske universitet | en_US |
| dc.publisher | UiT The Arctic University of Norway | en_US |
| dc.rights.accessRights | openAccess | en_US |
| dc.rights.holder | Copyright 2018 The Author(s) | |
| dc.subject.courseID | DOKTOR-004 | |
| dc.subject | VDP::Mathematics and natural science: 400::Chemistry: 440::Inorganic chemistry: 442 | en_US |
| dc.subject | VDP::Matematikk og Naturvitenskap: 400::Kjemi: 440::Uorganisk kjemi: 442 | en_US |
| dc.title | Octaiodoporphyrin and Octaiodocorrole: Isolation of a Cis Porphyrin Tautomer | en_US |
| dc.type | Doctoral thesis | en_US |
| dc.type | Doktorgradsavhandling | en_US |
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