Blar i forfatter Artikler, rapporter og annet (farmasi) "Acharya, Ganesh"

Viser treff 1-5 av 5

    • Kan nanopartikulære formuleringer bedre behandlingen av genitale infeksjoner? 

      Jøraholmen, May Wenche; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-20)
      Bruk av nanoteknologi innenfor medisin er økende, og mange nanopartikulære såkalte «drug delivery-systemer» er allerede ute på markedet og enda flere er i pipeline. Det er blant annet stor interesse for bruk av polymeriske miceller, dendrimerer, liposomer og polymeriske nanopartikler som nanobærere for legemidler. Potensialet som ligger i bruk av nanoteknologi er fremdeles ikke fullt utnyttet ...

    • Liposomes-in-hydrogel delivery system enhances the potential of resveratrol in combating vaginal chlamydia infection 

      Jøraholmen, May Wenche; Johannessen, Mona; Gravningen, Kirsten Midttun; Puolakkainen, Mirja; Acharya, Ganesh; Basnet, Purusotam; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
      <i>Chlamydia trachomatis</i> is the most common cause of bacterial sexually transmitted infections and causes serious reproductive tract complications among women. The limitations of existing oral antibiotics and treatment of antimicrobial resistance require alternative treatment options. We are proposing, for the first time, the natural polyphenol resveratrol (RES) in an advanced delivery system ...

    • PEGylated liposomes for topical vaginal therapy improve delivery of interferon alpha 

      Jøraholmen, May Wenche; Basnet, Purusotam; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-11)
      Recent studies regarding mucosal drug delivery indicate that nanosystems with surface-available polyethylene glycol (PEG) are able to penetrate mucus barrier, assure closer contact with the epithelium, and improve drug delivery to vagina. In the present work, we developed the mucus-penetrating PEGylated liposomes containing interferon alpha-2b (IFN α-2b), destined to provide localized therapy for ...

    • Resveratrol-loaded liposomes for topical treatment of the vaginal inflammation and infections 

      Jøraholmen, May Wenche; Skalko-Basnet, Natasa; Acharya, Ganesh; Basnet, Purusotam (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-07)
      Resveratrol (RES), chemically known as 3,5,4′-trihydroxy-trans-stilbene, is a promising multi-targeted antioxidative and anti-inflammatory natural polyphenol. Preclinical studies showed its biological activities against the pathogens of sexually transmitted diseases causing vaginal inflammation and infections. Due to its low solubility and poor bioavailability, the optimal therapeutic uses are ...

    • Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginal Tissue Model 

      Jøraholmen, May Wenche; Damdimopoulou, Pauliina; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-17)
      The natural polyphenol resveratrol (RES) has shown great potential as an antimicrobial, including against microbes associated with vaginal infections. To fully exploit the activities of RES, an all-natural ingredients formulation for RES delivery at vaginal site has been developed, namely liposomes loaded with RES, incorporated into a chitosan hydrogel as secondary vehicle. Although considered ...