Blar i forfatter Artikler, rapporter og annet (farmasi) "Isaksson, Johan"

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    • Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates 

      Paulsen, Marianne Hagensen; Engqvist, Magnus; Ausbacher, Dominik; Anderssen, Trude; Langer, Manuel Karl; Haug, Tor; Morello, Glenn Robert; Liikanen, Laura; Blencke, Hans-Matti; Isaksson, Johan; Juskewitz, Eric; Bayer, Annette; Strøm, Morten B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-27)
      We report a series of synthetic cationic amphipathic barbiturates inspired by the pharmacophore model of small antimicrobial peptides (AMPs) and the marine antimicrobials eusynstyelamides. These N,N′-dialkylated-5,5-disubstituted barbiturates consist of an achiral barbiturate scaffold with two cationic groups and two lipophilic side chains. Minimum inhibitory concentrations of 2–8 μg/mL were achieved ...

    • Beta-glucan-loaded nanofiber dressing improves wound healing in diabetic mice 

      Grip, Jostein; Engstad, Rolf Einar; Skjæveland, Ingrid; Skalko-Basnet, Natasa; Isaksson, Johan; Basnet, Purusotam; Holsæter, Ann Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-01)
      The increased prevalence of chronic wounds requires novel treatment options. The aim of this study was to develop a beta-glucan (βG)-loaded nanofiber wound dressing. Nanofibers were prepared using the needle-free Nanospider™ technology, an electrospinning method which enables the production of nanofibers at an industrial scale. The βG was selected as active ingredient based on its confirmed wound ...

    • Development of a biomimetic phospholipid vesicle-based permeation assay for the estimation of intestinal drug permeability 

      Naderkhani, Elenaz; Isaksson, Johan; Ryzhakov, Alexey; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)