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norskArtikler, rapporter og annet (farmasi): Recent submissions
Now showing items 81-100 of 391
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Nucleic acid peptide nanogels for the treatment of bacterial keratitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-14)Cage-shaped nucleic acid nanocarriers are promising molecular scaffolds for the organization of polypeptides. However, there is an unmet need for facile loading strategies that truly emulate nature's host–guest systems to drive encapsulation of antimicrobial peptides (AMPs) without loss of biological activity. Herein, we develop DNA nanogels with rapid in situ loading of L12 peptide during the thermal ... -
How docetaxel entrapment, vesicle size, zeta potential and stability change with liposome composition–A formulation screening study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-21)Limitations of the anticancer drug product Taxotere® have encouraged researchers to entrap the active ingredient docetaxel (DTX) into nanocarriers such as liposomes. However, until now no DTX-liposome formulation has reached the clinic. Hence, in the present study, different Soy-PC based DTX-liposome formulations were screened in an attempt to identify lipid-compositions with promising DTX-entrapment ... -
Genetically determined reproductive aging and coronary heart disease: a bidirectional two-sample Mendelian Randomization
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-20)Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause.<p> <p>Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD ... -
Pharmacist's time spent: Space for Pharmacy-based Interventions and Consultation TimE (SPICE)-an observational time and motion study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-02)Objective To describe the pharmacists’ workflow, including tasks and time spent, to better understand their work capacity.<p> <p>Design Cross-sectional, observational, time and motion study. <p>Setting Community pharmacies in Western Australia and New South Wales, Australia. <p>Participants Currently registered and practising pharmacists were approached using snowball sampling and selected ... -
Medication adherence among persons with coronary heart disease and associations with blood pressure and low-density-lipoprotein-cholesterol
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-21)Purpose - To describe medication adherence to lipid-lowering drugs (LLDs), antihypertensive drugs, and acetylsalicylic acid (ASA) among persons with coronary heart disease (CHD) and explore its association with low-density-lipoprotein (LDL)-cholesterol, and systolic and diastolic blood pressure.<p> <p>Methods - Based on record linkage between the seventh wave of the Tromsø Study and the Norwegian ... -
Effect of antiangiogenic therapy on tumor growth, vasculature and kinase activity in basal- and luminal-like breast cancer xenografts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-03-31)Several clinical trials have investigated the efficacy of bevacizumab in breast cancer, and even if growth inhibiting effects have been registered when antiangiogenic treatment is given in combination with chemotherapy no gain in overall survival has been observed. One reason for the lack of overall survival benefit might be that appropriate criteria for selection of patients likely to respond ... -
Toxicity Assessment of Resveratrol Liposomes-in-Hydrogel Delivery System by EpiVaginal Tissue Model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-17)The natural polyphenol resveratrol (RES) has shown great potential as an antimicrobial, including against microbes associated with vaginal infections. To fully exploit the activities of RES, an all-natural ingredients formulation for RES delivery at vaginal site has been developed, namely liposomes loaded with RES, incorporated into a chitosan hydrogel as secondary vehicle. Although considered ... -
The pH-Responsive Liposomes—The Effect of PEGylation on Release Kinetics and Cellular Uptake in Glioblastoma Cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-25)Nanomedicine has been, to a certain degree, a success story in the development of superior anticancer therapies. However, there are tumors that remain a huge challenge for nanoformulations, for instance, brain tumors such as glioblastoma, the most common and aggressive brain tumor. To utilize the fact that such tumors are characterized by an acidic extracellular environment, we selected pH-responsive ... -
Fitness costs of various mobile genetic elements in Enterococcus faecium and Enterococcus faecalis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013-07-05)Objectives: To determine the fitness effects of various mobile genetic elements (MGEs) in Enterococcus faecium and Enterococcus faecalis when newly acquired. We also tested the hypothesis that the biological cost of vancomycin resistance plasmids could be mitigated during continuous growth in the laboratory.<p> <p>Methods: Different MGEs, including two conjugative transposons (CTns) of the Tn916 ... -
Crosstalk between p38 MAPK and GR Signaling
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-19)The p38 MAPK is a signaling pathway important for cells to respond to environmental and intracellular stress. Upon activation, the p38 kinase phosphorylates downstream effectors, which control the inflammatory response and coordinate fundamental cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of this signaling pathway has been linked to inflammatory diseases ... -
Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A<sub>2</sub>, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-09-16)Arachidonic acid metabolism leads to the generation of key lipid mediators which play a fundamental role during inflammation. The inhibition of enzymes involved in arachidonic acid metabolism has been considered as a synergistic anti-inflammatory effect with enhanced spectrum of activity. A series of 1,3-diphenyl-2-propen-1-one derivatives were investigated for anti-inflammatory related activities ... -
Selective serotonin reuptake inhibitors during pregnancy and risk of persistent pulmonary hypertension in the newborn: population based cohort study from the five Nordic countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-01-12)Objective To assess whether maternal use of selective serotonin reuptake inhibitors (SSRIs) increases the risk of persistent pulmonary hypertension in the newborn, and whether such an effect might differ between specific SSRIs.<p> <p>Design Population based cohort study using data from the national health registers.<p> <p>Setting Denmark, Finland, Iceland, Norway, and Sweden, 1996-2007.<p> ... -
vCOMBAT: a novel tool to create and visualize a computational model of bacterial antibiotic target-binding
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-06)Background: As antibiotic resistance creates a signifcant global health threat, we need not only to accelerate the development of novel antibiotics but also to develop better treatment strategies using existing drugs to improve their efcacy and prevent the selection of further resistance. We require new tools to rationally design dosing regimens from data collected in early phases of antibiotic ... -
Biologics: the role of delivery systems in improved therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-19)The beginning of the 21st century saw numerous protein and peptide therapeuticals both on the market and entering the final stages of clinical studies. They represent a new category of biologically originated drugs termed biologics or biologicals. Their main advantages over conventional drugs can be summarized by their high selectivity and potent therapeutic efficacy coupled with limited side ... -
Detection of carbapenemases with a newly developed commercial assay using Matrix Assisted Laser Desorption Ionization-Time of Flight
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-03)This study evaluated the performance of the MBT STAR-Carba kit (Bruker Daltonics), to detect carbapenemase producing Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp. in comparison with the RAPIDEC® CARBA NP test (BioMerieux). MBT STAR-Carba allowed the detection of carbapenemases in Enterobacteriaceae and P. aeruginosa. -
The effect of low-dose naltrexone on medication in inflammatory bowel disease: A quasi experimental before-and-after prescription database study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-27)Background and Aims: Low-dose naltrexone [LDN] is a controversial off-label treatment used by many Crohn’s disease [CD] and ulcerative colitis [UC] patients. A small number of preliminary studies indicate that LDN might be beneficial in CD, but evidence is too scarce to demonstrate efficacy. We sought to examine whether initiation of LDN therapy by patients with inflammatory bowel disease [IBD] ... -
Performance of the EUCAST disc diffusion method and two MIC methods in detection of Enterobacteriaceae with reduced susceptibility to meropenem: the NordicAST CPE study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-24)Objectives: To examine performance of EUCAST disc diffusion and supplementary MIC methods for detection of Enterobacteriaceae with reduced susceptibility to meropenem using EUCAST screening recommendations.<p> <p>Methods: Sixty-one Nordic laboratories delivered data on EUCAST disc diffusion (n " 61), semi-automated meropenem MIC (n " 23; VITEK2, n " 20 and Phoenix, n " 3) and gradient meropenem ... -
Detection of DHCMT long-term metabolite glucuronides with LC-MSMS as an alternative approach to conventional GC-MSMS analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-17)Dehydrochloromethyltestosterone (DHCMT) is one of the most detected illicit used anabolic–androgenic steroids in professional sports. Therefore, a fast and accurate analysis of this substance is of great importance for a constructive fight against doping abuse. The conventional method for the analysis of this drug, GC-MSMS, is very sensitive and selective but also very time- and resource-consuming. ... -
Drug loading to mesoporous silica carriers by solvent evaporation: A comparative study of amorphization capacity and release kinetics
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-08)The sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement for this challenging group of substances. However, the success of this approach for a particular API depends on an array of factors including the properties of the porous carrier, the loading method, or the attempted ... -
Self-medication Behavior with antibiotics: a national cross-sectional survey in Sri Lanka
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-14)<b><p>Background</b> Antibiotic self-medication is common in low- and middle-income countries. This study aimed to evaluate the Sri Lankan public’s knowledge about and attitudes toward antibiotic use and self-medication, and factors associated with self-medication. <b><p>Methods</b> A national cross-sectional, interviewer-administered, survey of a random household sample (N = 1100) was ...
