Artikler, rapporter og annet (farmasi): Nye registreringer

Viser treff 301-320 av 391

    • Liposomal formulations of poorly soluble camptothecin: drug retention and biodistribution 

      Flaten, Gøril Eide; Chang, Ting-Tung; Phillips, William T.; Brandl, Martin; Bao, Ande; Goins, Beth (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-12-05)
      Context: Camptothecin (CPT) represents a potent anticancer drug. Its therapeutic use however is impaired by both drug solubility, hydrolysis and protein interactions in vivo. Use of liposomes as drug formulation approach could overcome some of these challenges. <p>Objective: The objective of this study was to perform a mechanistic study of the incorporation and retention of the lipophilic parent ...

    • Drug permeability across a phospholipid vesicle-based barrier: 4. The effect of tensides, co-solvent and pH changes on barrier integrity and on drug permeability 

      Flaten, Gøril Eide; Luthman, Kristina; Vasskog, Terje; Brandl, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-07-03)
      In this study the integrity of the recently developed phospholipid vesicle-based permeability barrier in the presence of a variety of co-solvents and tensides has been investigated. Also included are studies of the influence of these additives on drug permeation and the effect of pH changes on the permeability of ionogenic drug compounds. Permeability experiments using the hydrophilic model ...

    • Aerobic treatment of selective serotonin reuptake inhibitors in landfill leachate 

      Bergersen, Ove; Østnes Hanssen, Kine; Vasskog, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-28)
      Background: Pharmaceuticals used in human medical care are not completely eliminated in the human body and can enter the municipal sewage sludge system and leachate water from landfill both as the parent compound and as their biologically active metabolites. The selective serotonin reuptake inhibitors (SSRIs) have a large potential for unwanted effects on nontarget organisms in the environment. ...

    • Review of GMO safety assessment studies: glyphosate residues in Roundup Ready crops is an ignored issue 

      Cuhra, Marek (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-10)
      <p><i>Background - </i>Genetically modified glyphosate-tolerant cultivar varieties have been a commercial success widely known as Roundup Ready plants. As new glyphosate-tolerant varieties are introduced to satisfy agriculture demand, it is relevant to review the scientific evidence that documents the quality and safety of such biotechnology. Assessments of genetically modified glyphosate-tolerant ...

    • Progress toward rationally designed small-molecule peptide and peptidomimetic CXCR4 antagonists 

      Våbenø, Jon; Haug, Bengt Erik; Rosenkilde, Mette M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06)
      Over the last five years, X-ray structures of CXC chemokine receptor 4 (CXCR4) in complex with three different ligands (the small-molecule antagonist IT1t, the polypeptide antagonist CVX15, and the viral chemokine antagonist vMIP-II) have been released. In addition to the inherent scientific value of these specific X-ray structures, they (i) provide a reliable structural ...

    • The Seralini affair: degeneration of Science to Re-Science? 

      Fagan, John; Traavik, Terje; Bøhn, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-29)
      A paper reporting findings relevant to safety of the genetically modified (GM) maize NK603 and the herbicide Roundup (Séralini et al., Food Chem Toxicol. 50:4221–4231, 2012) was retracted against the wishes of the authors, and subsequently republished in another peer-reviewed journal (Séralini et al. Environ Sci Europe, doi:10.1186/s12302- 014-0014-5, 2014). These events exemplify a trend in which ...

    • Kan nanopartikulære formuleringer bedre behandlingen av genitale infeksjoner? 

      Jøraholmen, May Wenche; Acharya, Ganesh; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-20)
      Bruk av nanoteknologi innenfor medisin er økende, og mange nanopartikulære såkalte «drug delivery-systemer» er allerede ute på markedet og enda flere er i pipeline. Det er blant annet stor interesse for bruk av polymeriske miceller, dendrimerer, liposomer og polymeriske nanopartikler som nanobærere for legemidler. Potensialet som ligger i bruk av nanoteknologi er fremdeles ikke fullt utnyttet ...

    • Probing the molecular interactions between CXC chemokine receptor 4 (CXCR4) and an arginine-based tripeptidomimetic antagonist (KRH-1636) 

      Zachariassen, Zack George; Karlshøj, Stefanie; Haug, Bengt Erik; Rosenkilde, Mette M.; Våbenø, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-23)
      We here report an experimentally verified binding mode for the known tripeptidomimetic CXCR4 antagonist KRH-1636 (1). A limited SAR study based on the three functionalities of 1 was first conducted, followed by site-directed mutagenesis studies. The receptor mapping showed that both the potency and affinity of 1 were dependent on the transmembrane residues His113, Asp171, Asp262, and His281 and also ...

    • Efflux pump-mediated drug resistance in Burkholderia 

      Podnecky, Nicole; Rhodes, Katherine A.; Schweizer, Herbert P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-14)
      Several members of the genus Burkholderia are prominent pathogens. Infections caused by these bacteria are difficult to treat because of significant antibiotic resistance. Virtually all Burkholderia species are also resistant to polymyxin, prohibiting use of drugs like colistin that are available for treatment of infections caused by most other drug resistant Gram-negative bacteria. Despite clinical ...

    • Analysis of Bottlenecks in Experimental Models of Infection 

      Abel, Sören; Schulz Zur Wiesch, Pia; Davis, Brigid M.; Waldor, Matthew K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-11)

    • A pharmacist-led follow-up program for patients with established coronary heart disease in North Norway – A randomized controlled trial [Programa farmacéutico de seguimiento para pacientes con enfermedad coronaria establecida en El Norte de Noruega – Ensayo controlado aleatorizado] 

      Garcia, Beate Hennie; Giverhaug, Trude; Høgli, June U.; Skjold, Frode; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06)
      OBJECTIVES: The aim of the study was twofold; 1) to develop a clinical pharmacist-led 12 month lasting follow-up program for patients with established coronary heart disease (CHD) discharged from the University Hospital of North Norway, and 2) to explore the impact of the program with regards to adherence to a medication assessment tool for secondary prevention of CHD and change in biomedical ...

    • Persistence of a pKPN3-like CTX-M-15-encoding IncFIIK plasmid in a Klebsiella pneumonia ST17 host during two years of intestinal colonization 

      Löhr, Iren Høyland; Hülter, Nils Fredrik; Bernhoff, Eva; Johnsen, Pål Jarle; Sundsfjord, Arnfinn; Naseer, Mohammed Umaer (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-04)
      Objectives To characterize the CTX-M-15-encoding plasmid in a Klebsiella pneumoniae ST17 strain, responsible for an outbreak at a Norwegian neonatal intensive care unit and subsequent colonization of affected children for up to two years. To identify plasmid-mediated features relevant for the outbreak dynamics, and to investigate the plasmids capability of horizontal transfer, its segregational ...

    • Glyphosate non-toxicity: the genesis of a scientific fact 

      Cuhra, Marek (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-30)
      Repetition of a 1978 experiment on the toxicity of glyphosate chemicals in water-flea Daphnia magna showed surprising results. In the 31 years which had passed between the two series of experiments, the toxicity of glyphosate had apparently become 300 times stronger! Further investigation into this enigmatic paradox discloses unfortunate aspects of laboratory researcher cultures as well as fundamental ...

    • Chronic Responses of Daphnia magna under Dietary Exposure to Leaves of a Transgenic (Event MON810) Bt-Maize Hybrid and its Conventional Near-Isoline 

      Holderbaum, Daniel Ferreira; Cuhra, Marek; Wickson, Fern; Orth, Afonso Inácio; Nodari, Rubens Onofre; Bøhn, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-11)
      Insect resistance is the second most common trait globally in cultivated genetically modified (GM) plants. Resistance is usually obtained by introducing into the plant’s genome genes from the bacterium Bacillus thuringiensis (Bt) coding for insecticidal proteins (Cry proteins or toxins) that target insect pests. The aim of this study was to examine the hypothesis that a chronic, high-dose dietary ...

    • Involvement of aph(3')-IIa in the formation of mosaic aminoglycoside resistance genes in natural environments 

      Woegerbauer, Markus; Kuffner, Melanie; Domingues, Sara; Nielsen, Kaare Magne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-19)
      Intragenic recombination leading to mosaic gene formation is known to alter resistance profiles for particular genes and bacterial species. Few studies have examined to what extent aminoglycoside resistance genes undergo intragenic recombination. We screened the GenBank database for mosaic gene formation in homologs of the aph(3′)-IIa (nptII) gene. APH(3′)-IIa inactivates important aminoglycoside ...

    • Biomimetic PVPA in vitro model for estimation of the intestinal drug permeability using fasted and fed state simulated intestinal fluids 

      Naderkhani, Elenaz; Vasskog, Terje; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-20)
      A prerequisite for successful oral drug therapy is the drug’s ability to cross the gastrointestinal barrier. Considering the increasing number of new chemical entities in modern drug discovery, reliable and fast in vitro models are required for early and efficient prediction of intestinal permeability. To mimic the intestinal environment, use of biorelevant media may provide valuable information ...

    • Drug permeability across a phospholipid vesicle-based barrier - 2. Characterization of barrier structure, storage stability and stability towards pH changes 

      Flaten, Gøril Eide; Bunjes, Heike; Luthman, Kristina; Brandl, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2006-04-18)
      Recently we reported on the development of a phospholipid vesicle-based barrier as a medium throughput method for screening of drug permeability. The aim of this present study is to characterize the barrier structure, including an estimation of the amount of phospholipid within it, its storage stability and its stability over various pH ranges found in different parts of the gastrointestinal tract. ...

    • In vitro skin models as a tool in optimization of drug formulation 

      Flaten, Gøril Eide; Palac, Zora; Engesland, André; Filipović-Grčić, Jelena; Vanić, Željka; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-30)
      (Trans)dermal drug therapy is gaining increasing importance in the modern drug development. To fully utilize the potential of this route, it is important to optimize the delivery of active ingredient/drug into/through the skin. The optimal carrier/vehicle can enhance the desired outcome of the therapy therefore the optimization of skin formulations is often included in the early stages of the ...

    • The Phospholipid Vesicle-Based Drug Permeability Assay: 5. Development Toward an Automated Procedure for High-Throughput Permeability Screening 

      Flaten, Gøril Eide; Awoyemi, Opeyemi Linda Ronke; Luthman, Kristina; Brandl, Martin; Massing, Ulrich (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-02)
      In-vitro screening for oral absorption has become an essential part of drug discovery and development. Recently, a new phospholipid vesicle-based permeation assay was developed which has shown to satisfyingly predict passive absorption of drugs in humans. The purpose of the current study was to investigate whether the assay may be further developed into a high-throughput tool by automating its ...

    • Antibiotic delivery by liposomes from prokaryotic microorganisms: Similia cum similis works better 

      Colzi, Ilaria; Troyan, Anna N.; Perito, Brunella; Casalone, Enrico; Romoli, Riccardo; Pieraccini, Giuseppe; Skalko-Basnet, Natasa; Adessi, Alessandra; Rossi, Federico; Gonnelli, Cristina; Ristori, Sandra (Journal article; Preprint; Tidsskriftartikkel; Peer reviewed; Manuskript, 2015-06-25)
      To date the effectiveness of antibiotics is undermined by microbial resistance, threatening public health worldwide. Enhancing the efficacy of the current antibiotic arsenal is an alternative strategy. The administration of antimicrobials encapsulated in nanocarriers, such as liposomes, is considered a viable option, though with some drawbacks related to limited affinity between conventional liposomes ...