Artikler, rapporter og annet (farmasi): Nye registreringer

Viser treff 341-360 av 391

    • Phospholipid Vesicle-Based Permeation Assay and EpiSkin in Assessment of Drug Therapies Destined for Skin Administration 

      Engesland, André; Skalko-Basnet, Natasa; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Elastic liposomes-in-vehicle formulations destined for skin therapy: the synergy between type of liposomes and vehicle 

      Palac, Zora; Hurler, Julia; Skalko-Basnet, Natasa; Filipovic-Grcic, Jelena; Vanic, Zeljka (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-14)

    • Liposomes for (trans)dermal drug delivery: the skin-PVPA as a novel in vitro stratum corneum model in formulation development 

      Palac, Zora; Engesland, André; Flaten, Gøril Eide; Skalko-Basnet, Natasa; Filipovic-Grcic, Jelena; Vanic, Zeljka (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-19)
      Penetration potential of vesicles destined for trans(dermal) administration remains to be of great interests both in respect to drug therapy and cosmetic treatment. This study investigated the applicability of the phospholipid vesicle-based permeation assay (PVPA) as a novel in vitro skin barrier model for screening purposes in preformulation studies. Various classes of liposomes containing hydrophilic ...

    • Chitosan-coated liposomes for topical vaginal therapy: Assuring localized drug effect 

      Jøraholmen, May Wenche; Vanić, Željka; Tho, Ingunn; Škalko-Basnet, Nataša (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      The choice of drug therapy in pregnant patients suffering from vaginal infections is limited by the safety profile of the drug. Assuring the efficient topical therapy to avoid systemic absorption is considered the best therapy option. Chitosan-coated liposomes have been developed and optimized to assure localized therapy of clotrimazole. Chitosan was selected as mucoadhesive polymer both to prolong ...

    • Improved Permeability of Acyclovir: Optimization of Mucoadhesive Liposomes Using the Phospholipid Vesicle-Based Permeation Assay 

      Naderkhani, Elenaz; Erber, Astrid; Skalko-Basnet, Natasa; Flaten, Gøril Eide (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-01-06)

    • Bioadhesive Mini-Tablets for Vaginal Drug Delivery 

      Hiorth, Marianne; Nilsen, Susanne; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-08-27)

    • Chitosan in Mucoadhesive Drug Delivery: Focus on Local Vaginal Therapy 

      Andersen, Toril; Bleher, Stefan; Flaten, Gøril Eide; Tho, Ingunn; Mattsson, Sofia; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-07)
      Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today’s drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers means to improve mucosal drug therapy. We have used chitosan as mucoadhesive polymer to develop liposomes able to ensure prolonged residence time at vaginal site. Two types of ...

    • Antibiotikaresistens - kunnskapshull, utfordringer og aktuelle tiltak. Rapport fra tverrsektoriell ekspertgruppe 

      Steinbakk, Martin; Sunde, Marianne; Urdal, Anne Margrete; Barkbu, Kjersti Nilsen; Sørum, Henning; Lunestad, Bjørn Tore; Bonhorst, Janne Øvrebø; Nielsen, Kaare Magne; Lindbæk, Morten; Bjørnholt, Jørgen (Research report; Forskningsrapport, 2014)

    • Molecular characterization and phylogenetics of Fennoscandian cowpox virus isolates based on the p4c and atip genes 

      Okeke, Malachy Ifeanyi; Okoli, Arinze Stanley; Nilssen, Øivind; Moens, Ugo; Tryland, Morten; Bøhn, Thomas; Traavik, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Background: Cowpox virus (CPXV), a rodent-borne Orthopoxvirus (OPV) that is indigenous to Eurasia can infect humans, cattle, felidae and other animals. Molecular characterization of CPXVs isolated from different geographic locations is important for the understanding of their biology, geographic distribution, classification and evolution. Our aim was to characterize CPXVs isolated from Fennoscandia ...

    • Risk assessment of GM trees in the EU: current regulatory framework and guidance 

      Aguilera, J.; Nielsen, Kåre M.; Sweet, J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The use of genetically modified organisms - their release into the environment, import, and utilisation as food/feed or food/feed ingredients - is regulated in the European Union (EU). For placing onto the market, current legislations require a comprehensive and science-based risk assessment. This risk assessment (RA) is performed by applicants and then evaluated by national authorities in close ...

    • Liposomes-in-Hydrogel Delivery System with Mupirocin: In Vitro Antibiofilm Studies and In Vivo Evaluation in Mice Burn Model 

      Hurler, Julia; Sørensen, Karen Kristine; Fallalero, Adyary; Vuorela, Pia; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Previously, we have proposed mupirocin-in-liposomes-in-hydrogel delivery system as advanced delivery system with the potential in treatment of burns. In the current studies, we evaluated the system for its cytotoxicity, ability to prevent biofilm formation, act on the mature biofilms, and finally determined its potential as wound treatment in in vivo mice burn model.The system was found to be ...

    • Clone- and age-dependent toxicity of a glyphosate commercial formulation and its active ingredient in Daphnia magna. 

      Cuhra, Marek; Traavik, Terje; Bøhn, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Low levels of glyphosate based herbicide induced significant negative effects on the aquatic invertebrate Daphnia magna. Glyphosate herbicides such as brands of Roundup, are known to be toxic to daphnids. However, published findings on acute toxicity show significant discrepancies and variation across several orders of magnitude. To test the acute effects of both glyphosate and a commercial ...

    • Osteopontin is a prognostic biomarker in non-small cell lung cancer 

      Rud, Ane Kristine Kongsgaard; Pedersen, Kjetil Boye; Øijordsbakken, Miriam; Lund-Iversen, Marius; Halvorsen, Ann Rita; Solberg, Steinar; Berge, Gisle; Helland, Åslaug; Brustugun, Odd Terje; Mælandsmo, Gunhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: In a previously published report we characterized the expression of the metastasis-associated proteins S100A4, osteopontin (OPN) and ephrin-A1 in a prospectively collected panel of non-small cell lung cancer (NSCLC) tumors. The aim of the present follow-up study was to investigate the prognostic impact of these potential biomarkers in the same patient cohort. In addition, circulating ...

    • Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer 

      Moestue, Siver Andreas; Dam, Cornelia Gerarda; Gorad, Saurabh Sayajirao; Kristian, Alexandr; Bofin, Anna M.; Mælandsmo, Gunhild; Engebråten, Olav; Gribbestad, Ingrid S; Bjørkøy, Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Introduction: The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in cancer cells through numerous mutations and epigenetic changes. The recent development of inhibitors targeting different components of the PI3K pathway may represent a valuable treatment alternative. However, predicting efficacy of these drugs is challenging, and methods for therapy monitoring are needed. ...

    • Characterization of extracellular polymeric matrix, and treatment of Fusobacterium nucleatum and Porphyromonas gingivalis biofilms with DNase I and proteinase K 

      Mohammed, Marwan; Nerland, Audun Helge; Al-Haroni, Mohammed; Bakken, Vidar (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Biofilms are organized communities of microorganisms embedded in a self-produced extracellular polymeric matrix (EPM), often with great phylogenetic variety. Bacteria in the subgingival biofilm are key factors that cause periodontal diseases; among these are the Gram-negative bacteria Fusobacterium nucleatum and Porphyromonas gingivalis. The objectives of this study were to characterize ...

    • Identical Miniature Inverted Repeat Transposable Elements Flank Class 1 Integrons in Clinical Isolates of Acinetobacter spp. 

      Domingues, Sara; Toleman, Mark A.; Nielsen, Kåre M.; da Silva, Gabriela J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Miniature inverted repeat transposable elements (MITEs) have been identified flanking class 1 integrons. We have identified and characterized a 439-bp MITE-like structure in seven Acinetobacter species isolates from Portugal and Brazil. The complete sequence similarity of the elements and flanking regions suggests that MITEs may act as mobilizable vectors for the dissemination of integrons.

    • Nanopharmaceuticals for improved topical vaginal delivery: Can they deliver? 

      Vanic, Zeljka; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Nanopharmaceuticals have the potential to revolutionise medical treatment by permitting the design of more potent, less toxic “smart” therapeutics, ultimately leading to personalised medicine. This review summarises the challenges and potential uses of nanodelivery system for the topical drug therapy of vaginal diseases. The vaginal route of drug administration remains a challenge in the development ...

    • The effect of lipid composition and liposome size on the release properties of liposomes-in-hydrogel 

      Hurler, Julia; Zakelj, Simon; Mravljak, Janez; Pajk, Stane; Kristl, Albin; Schubert, Rolf; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      To study the release of liposome-associated drugs into hydrogels, we designed and synthesized two pH-sensitive rhodamine derivatives to use as model compounds of different lipophilicities. The dyes were fluorescent when in the free form released from liposomes into the chitosan hydrogel, but not when incorporated within liposomes. The effect of liposomal composition, surface charge and vesicle size ...

    • Compositional differences in soybeans on the market: glyphosate accumulates in Roundup Ready GM soybeans 

      Bøhn, Thomas; Cuhra, Marek; Traavik, Terje; Sanden, Monica; Primicerio, Raul (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      This article describes the nutrient and elemental composition, including residues of herbicides and pesticides, of 31 soybean batches from Iowa, USA. The soy samples were grouped into three different categories: (i) genetically modified, glyphosate-tolerant soy (GM-soy); (ii) unmodified soy cultivated using a conventional ‘‘chemical’’ cultivation regime; and (iii) unmodified soy cultivated using an ...

    • Structure-activity relationship studies of the aromatic positions in cyclopentapeptide CXCR4 antagonists 

      Mungalpara, Jignesh; Zachariassen, Zack George; Thiele, Stefanie; Rosenkilde, MM; Våbenø, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The cyclopentapeptide CXCR4 antagonist FC131 (cyclo(-Arg1-Arg2-2-Nal3-Gly4-D-Tyr5-), 2; 2-Nal = 3-(2-naphthyl)alanine) represents an excellent starting point for development of novel drug-like ligands with therapeutic potential in HIV, cancer, stem-cell mobilization, inflammation, and autoimmune diseases. While the structure–activity relationships for Arg1, Arg2, and Gly4 are well established, less ...