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dc.contributor.authorJohnsen, Stein Harald
dc.contributor.authorJacobsen, Bjarne K.
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.contributor.authorMathiesen, Ellisiv B.
dc.date.accessioned2018-11-08T13:12:44Z
dc.date.available2018-11-08T13:12:44Z
dc.date.issued2018-05-25
dc.description.abstractBackground: <br>Whether long-chain n–3 PUFAs of marine origin have an anti-atherogenic effect in the general population has hardly been studied. In this population-based study, we hypothesized that fatty fish and fish oil intake protect against development of novel atherosclerotic plaques and is associated with reduced plaque size.<br> Methods: <br>We obtained questionnaire-based information on fish consumption and carotid ultrasonography from 3900 persons aged 45–74 years. The questionnaires were validated by measuring serum concentrations of PUFAs and triglycerides in a subgroup. At follow-up seven years later, 2983 (76%) went through a second ultrasound scanning. Logistic regression and general linear models were used to analyze the outcome (plaque presence and plaque area) as a function of fish consumption, including analyses stratified on fish oil supplements. <br>Results: <br>At baseline, lean fish intake < 1 time/week vs. 1–1.9 times/week was associated with risk of plaque (OR 1.34, 95% CI 1.03–1.76). Fatty fish intake and use of fish oil supplements were not statistically significantly associated with atherosclerosis at baseline. In persons without plaque at baseline, total fish consumption ≥3 times/week vs. 1–1.9 times/week was associated with risk of novel plaque (OR 1.32, 95% CI 1.01–1.73) and larger plaque area (1.76 mm2 vs. 1.46 mm2 , p = 0.02) at follow-up. Adjustments for use of fish oil supplements had no impact on the associations, and no interactions were seen between total, fatty or lean fish consumption and fish oil intake.<br> Conclusions: <br>We found no protective effect of fatty fish eating or fish oil supplements on atherosclerotic plaque formation or plaque area in a general population. Lean fish consumption was associated with a reduced risk for plaque in cross-sectional analysis, suggesting that the beneficial effects of fish consumption on atherosclerosis may be mediated through other mechanisms than n-3 PUFAs.en_US
dc.description.sponsorshipUiT Norges arktiske universiteten_US
dc.descriptionSource at: <a href=http://doi.org/10.1186/s12937-018-0364-8> http://doi.org/10.1186/s12937-018-0364-8</a>en_US
dc.identifier.citationJohnsen, S. H., Jacobsen, B. K., Brækkan, S. K., Hansen, J.-B. & Mathiesen, E. B. (2018). Fish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø study. <i>Nutrition Journal, 17</i>(56). http://doi.org/10.1186/s12937-018-0364-8en_US
dc.identifier.cristinIDFRIDAID 1587300
dc.identifier.doi10.1186/s12937-018-0364-8
dc.identifier.issn1475-2891
dc.identifier.urihttps://hdl.handle.net/10037/14136
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalNutrition Journal
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleFish consumption, fish oil supplements and risk of atherosclerosis in the Tromsø studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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