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dc.contributor.authorLappegård, Jostein
dc.contributor.authorEllingsen, Trygve
dc.contributor.authorHindberg, Kristian
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorNjølstad, Inger
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2019-01-15T08:55:22Z
dc.date.available2019-01-15T08:55:22Z
dc.date.issued2018-04-10
dc.description.abstractRed cell distribution width (RDW), a measure of variability in size of circulating erythrocytes, is associated with arterial cardiovascular disease (CVD), but the underlying mechanism remains unclear. We aimed to investigate the impact of chronic inflammation as measured by high sensitivity CRP (hs-CRP) on this relationship, and explore whether RDW could be a mediator in the causal pathway between inflammation and arterial CVD. Baseline characteristics, including RDW and hs-CRP were obtained from 5,765 individuals attending a population-based cohort study. We followed participants from inclusion in the fourth survey of the Tromsø Study (1994/95) until December 31st 2012. Multivariable Cox-regression models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI) for incident myocardial infarction (MI) and ischemic stroke across quintiles of hs-CRP and RDW. Subjects with hs-CRP in the highest quintile had 44% higher risk of MI (HR: 1.44, 95% CI 1.14-1.80), and 64% higher risk of ischemic stroke (HR: 1.64, 95% CI 1.20- 2.24) compared to subjects in the lowest quintile. RDW mediated 7.2% (95% CI 4.0- 30.8%) of the association between hs-CRP and ischemic stroke. Subjects with RDW in the highest quintile had 22% higher risk of MI (HR: 1.22, 95% CI 0.98-1.54) and 44% higher risk of ischemic stroke (HR: 1.44, 95% CI 1.06-1.97) compared to subjects in the lowest quintile. These risk estimates were slightly attenuated after adjustments for hs-CRP. Our findings suggest that chronic inflammation is not a primary mechanism underlying the relationship between RDW and arterial CVD.en_US
dc.description.sponsorshipStiftelsen Kristian Gerhard Jebsen: ? Helsenord: ?en_US
dc.descriptionSource at: <a href=http://doi.org/10.1055/s-0038-1651523> http://doi.org/10.1055/s-0038-1651523</a>en_US
dc.identifier.citationLappegård, J., Ellingsen, T., Hindberg, K., Mathiesen, E. B., Njølstad, I., Wilsgaard, T., ... Hansen, J.-B. (2018). Impact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Study. <i>TH Open</i>, 2018, e182-e189. http://doi.org/10.1055/s-0038-1651523en_US
dc.identifier.cristinIDFRIDAID 1585908
dc.identifier.doi10.1055/s-0038-1651523
dc.identifier.issn2512-9465
dc.identifier.urihttps://hdl.handle.net/10037/14445
dc.language.isoengen_US
dc.publisherThiemeen_US
dc.relation.journalTH Open
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en_US
dc.titleImpact of Chronic Inflammation, Assessed by hs-CRP, on the Association between Red Cell Distribution Width and Arterial Cardiovascular Disease: The Tromsø Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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