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dc.contributor.authorArnstad, Ellen Dalen
dc.contributor.authorRypdal, Veronika Gjertsen
dc.contributor.authorPeltoniemi, Suvi
dc.contributor.authorHerlin, T
dc.contributor.authorBerntson, Lillemor
dc.contributor.authorFasth, Anders
dc.contributor.authorNielsen, Susan
dc.contributor.authorGlerup, Mia
dc.contributor.authorEkelund, Maria
dc.contributor.authorZak, Marek
dc.contributor.authorAalto, Kristiina
dc.contributor.authorNordal, Ellen Berit
dc.contributor.authorRomundstad, Pål Richard
dc.contributor.authorRygg, Marite
dc.date.accessioned2019-01-24T11:51:34Z
dc.date.available2019-01-24T11:51:34Z
dc.date.issued2018-07-28
dc.description.abstract<p><i>Objective</i>: To study self‐reported pain early in the disease course of juvenile idiopathic arthritis (JIA) as predictor of long‐term disease outcomes.</p> <p><i>Methods</i>: Consecutive cases of JIA with disease onset 1997‐2000 from defined geographical areas of Norway, Sweden, Finland and Denmark were prospectively enrolled in this population‐based cohort study. Self‐reported, disease‐related pain was measured on a 10 cm visual analogue scale (VAS pain). Inclusion criteria were a baseline visit with pain score six months after disease onset, followed by an eight‐year study visit. Remission was defined according to Wallace preliminary criteria. Functional disability was measured by Childhood Health Assessment Questionnaire (CHAQ) and Child Health Questionnaire (CHQ‐PF50) if age <18 and Health Assessment Questionnaire (HAQ) if age ≥18 years. Damage was scored using the Juvenile Arthritis Damage Index (JADI).</p> <p><i>Results</i>: The final study cohort consisted of 243 participants, and 120 (49%) had oligoarticular onset. At baseline 76% reported VAS pain >0 compared to 57% at eight‐year. Half of those who reported baseline pain also reported pain at eight‐year, but at a lower intensity. Compared to no pain, higher pain intensity at baseline predicted more pain at eight‐year, more functional disability, more damage and less remission off medication. Baseline pain predicted more use of DMARDs/biologics during the disease course. Participants with oligoarticular JIA reporting pain at baseline were more likely to develop extended oligoarticular or other unfavorable JIA categories.</p> <p><i>Conclusion</i>: Early self‐reported, disease‐related pain among children and adolescents with JIA is common and seems to predict persistent pain and unfavorable long‐term disease outcomes.en_US
dc.descriptionThis is the peer reviewed version of the following article: Arnstad, E.D., Rypdal, V., Peltoniemi, S., Herlin, T., Berntson. L., Fasth, A., ..., Rygg, M.. Early self-reported pain in juvenile idiopathic arthritis (JIA) is related to long-term outcomes. Results from the Nordic JIA cohort study. <i>Arthritis care & research</i>, which has been published in final form at <a href=https://doi.org/10.1002/acr.23715> https://doi.org/10.1002/acr.23715</a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationArnstad, E.D., Rypdal, V., Peltoniemi, S., Herlin, T., Berntson. L., Fasth, A., ..., Rygg, M.. Early self-reported pain in juvenile idiopathic arthritis (JIA) is related to long-term outcomes. Results from the Nordic JIA cohort study. <i>Arthritis care & research</i>. https://doi.org/10.1002/acr.23715en_US
dc.identifier.cristinIDFRIDAID 1651332
dc.identifier.doi10.1002/acr.23715
dc.identifier.issn2151-4658
dc.identifier.urihttps://hdl.handle.net/10037/14527
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalArthritis care & research
dc.rights.accessRightsopenAccessen_US
dc.subject.hrcsBetennelse og immunsystem: Underbyggende Forskning
dc.subject.hrcsInflammatory and Immune System: Underpinning Research
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.titleEarly self-reported pain in juvenile idiopathic arthritis (JIA) is related to long-term outcomes. Results from the Nordic JIA cohort study.en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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