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dc.contributor.authorKonieczny, Joanna
dc.contributor.authorArranz, Lorena
dc.date.accessioned2019-02-20T13:13:52Z
dc.date.available2019-02-20T13:13:52Z
dc.date.issued2018-08-29
dc.description.abstractBlood formation, or haematopoiesis, originates from haematopoietic stem cells (HSCs), whose functions and maintenance are regulated in both cell- and cell non-autonomous ways. The surroundings of HSCs in the bone marrow create a specific niche or microenvironment where HSCs nest that allows them to retain their unique characteristics and respond rapidly to external stimuli. Ageing is accompanied by reduced regenerative capacity of the organism affecting all systems, due to the progressive decline of stem cell functions. This includes blood and HSCs, which contributes to age-related haematological disorders, anaemia, and immunosenescence, among others. Furthermore, chronological ageing is characterised by myeloid and platelet HSC skewing, inflammageing, and expanded clonal haematopoiesis, which may be the result of the accumulation of preleukaemic lesions in HSCs. Intriguingly, haematological malignancies such as acute myeloid leukaemia have a high incidence among elderly patients, yet not all individuals with clonal haematopoiesis develop leukaemias. Here, we discuss recent work on these aspects, the ir potential underlying molecular mechanisms, and the first cues linking age-related changes in the HSC niche to poor HSC maintenance. Future work is needed for a better understanding of haematopoiesis during ageing. This field may open new avenues for HSC rejuvenation and therapeutic strategies in the elderlyen_US
dc.description.sponsorshipNorthern Norway Regional Health Authority University Hospital of Northern Norway (UNN) The Arctic University of Norway (UiT) (2014/5668) Norwegian Cancer Society (6765150) Northern Norway Regional Health Authority (HNF1338-17) Aakre-Stiftelsen Foundation (2016/9050)en_US
dc.descriptionSource at <a href=https://doi.org/10.3390/ijms19092567>https://doi.org/10.3390/ijms19092567. </a>en_US
dc.identifier.citationKonieczny, J. & Arranz, L. (2018). Updates on old and weary haematopoiesis. <i>International Journal of Molecular Sciences, 19</i>(9), 2567. https://doi.org/10.3390/ijms19092567en_US
dc.identifier.cristinIDFRIDAID 1610293
dc.identifier.doi10.3390/ijms19092567
dc.identifier.issn1422-0067
dc.identifier.urihttps://hdl.handle.net/10037/14729
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalInternational Journal of Molecular Sciences
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/FRIMEDBIO/250901/Norway/Stem Cell Metabolic Dysfunction in Myeloid Leukaemia and its Therapeutic Targeting//en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BEHANDLING/247596/Norway/Neuroglial Regulation of the Haematopoietic Stem Cell Niche in Acute Myeloid Leukaemia Transformation//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjecthaematopoiesisen_US
dc.subjectageingen_US
dc.subjectclonal haematopoiesisen_US
dc.subjectleukaemiaen_US
dc.subjectbone marrowen_US
dc.subjecthaematopoietic stem cell nicheen_US
dc.subjectinflammageingen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleUpdates on old and weary haematopoiesisen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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