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dc.contributor.authorIsaksen, Trond
dc.contributor.authorEvensen, Line Holtet
dc.contributor.authorJohnsen, Stein Harald
dc.contributor.authorJacobsen, Bjarne K.
dc.contributor.authorHindberg, Kristian
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2019-02-27T08:25:26Z
dc.date.available2019-02-27T08:25:26Z
dc.date.issued2018-12-13
dc.description.abstract<p><i>Background</i>: Studies on the association between long‐chained n‐3 polyunsaturated fatty acids (n‐3 PUFAs) and risk of venous thromboembolism (VTE) are conflicting, potentially due to challenges related to assessment of n‐3 PUFA intake and changes in diet during follow‐up.</p> <p><i>Objectives</i>: To investigate whether dietary intake of marine n‐3 PUFAs was associated with risk of incident VTE in a population‐based cohort with repeated assessments of n‐3 PUFA intake.</p> <p><i>Methods</i>: We recruited 21 970 participants (after excluding 7570 with incomplete data) from the fourth (1994‐1995) and sixth (2007‐2008) surveys of the Tromsø Study, and recorded incident VTEs up to 2016. Intake of n‐3 PUFAs was computed from self‐reported consumption of fat and lean fish, fish spread, and supplements. Cox proportional hazards regression models with n‐3 PUFA intake as a time‐varying variable were used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs) for VTE across quartiles (Q) of n‐3 PUFA intake.</p> <p><i>Results</i>: There were 541 incident VTEs during follow‐up. Compared to Q1, subjects in Q2‐4 had 22%‐26% lower risk of VTE (HR Q2 0.74, 95% CI 0.57‐0.96; HR Q3 0.77, 95% CI 0.59‐0.99; HR Q4 0.78, 95% CI 0.61‐1.00). The association was most pronounced for provoked VTE, particularly provoked pulmonary embolism (PE), with risk estimates of 0.42 (95% CI 0.25‐0.72), 0.40 (95% CI 0.23‐0.68), and 0.61 (95% CI 0.38‐0.96) for Q2‐4, respectively.</p> <p><i>Conclusions</i>: Dietary intake of marine n‐3 PUFAs was associated with a lower risk of VTE, particularly provoked PE. The association displayed a threshold pattern and suggested a protective effect of an n‐3 PUFA intake ≥4.7 g/week.</p>en_US
dc.description.sponsorshipStiftelsen Kristian Gerhard Jebsen UiT The Arctic University of Norwayen_US
dc.identifier.citationIsaksen, T., Evensen, L., Johnsen, S.H., Jacobsen, B.K., Hindberg, K., Brækkan, S.K. & Hansen, J.-B. (2019). Dietary intake of marine n- 3 polyunsaturated fatty acids and future risk of venous thromboembolism. <i>Research and Practice in Thrombosis and Haemostasis, 3</i>(1), 59-69. https://doi.org/10.1002/rth2.12168en_US
dc.identifier.cristinIDFRIDAID 1648562
dc.identifier.doi10.1002/rth2.12168
dc.identifier.issn2475-0379
dc.identifier.urihttps://hdl.handle.net/10037/14779
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.ispartofIsaksen, T. (2020). Dietary intake of marine polyunsaturated fatty acids and incidence, recurrence and mortality related to venous thromboembolism. (Doctoral thesis). <a href=https://hdl.handle.net/10037/19730>https://hdl.handle.net/10037/19730</a>.
dc.relation.journalResearch and Practice in Thrombosis and Haemostasis
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Hematology: 775en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Hematologi: 775en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en_US
dc.subjectdeep vein thrombosisen_US
dc.subjectdieten_US
dc.subjectomega‐3 fatty acidsen_US
dc.subjectpulmonary embolismen_US
dc.subjectrisk factorsen_US
dc.subjectvenous thromboembolismen_US
dc.titleDietary intake of marine n-3 polyunsaturated fatty acids and future risk of venous thromboembolismen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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