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dc.contributor.authorNakata, Mariko
dc.contributor.authorÅgmo, Anders j
dc.contributor.authorSatoshi, Shoko
dc.contributor.authorOgawa, Sonoko
dc.date.accessioned2019-03-19T14:31:13Z
dc.date.available2019-03-19T14:31:13Z
dc.date.issued2018-10-22
dc.description.abstractAcquisition of social dominance is important for social species including mice, for preferential access to foods and mates. Male mice establish social rank through agonistic behaviors, which are regulated by gonadal steroid hormone, testosterone, as its original form and aromatized form. It is well known that estrogen receptors (ERs), particularly ER α (ERα), mediate effects of aromatized testosterone, i.e., 17β-estradiol, but precise role played by ER β (ERβ) is still unclear. In the present study, we investigated effects of ERβ gene disruption on social rank establishment in male mice. Adult male ERβ knockout (βERKO) mice and their wild type (WT) littermates were paired based on genotype- and weight-matched manner and tested against each other repeatedly during 7 days experimental period. They underwent 4 trials of social interaction test in neutral cage (homogeneous set test) every other day. Along repeated trials, WT but not βERKO pairs showed a gradual increase of agonistic behaviors including aggression and tail rattling, and a gradual decrease of latency to social rank determination in tube test conducted after each trial of the social interaction test. Analysis of behavioral transition further suggested that WT winners in the tube test showed one-sided aggression during social interaction test suggesting WT pairs went through a process of social rank establishment. On the other hand, a dominant-subordinate relationship in βERKO pairs was not as apparent as that in WT pairs. Moreover, βERKO mice showed lower levels of aggressive behavior than WT mice in social interaction tests. These findings collectively suggest that ERβ may play a significant role in the establishment and maintenance of hierarchical social relationships among male mice.en_US
dc.description.sponsorshipThe Japan Society for the Promotion of Science (JSPS)en_US
dc.descriptionSource at <a href=https://doi.org/10.3389/fnbeh.2018.00245> https://doi.org/10.3389/fnbeh.2018.00245</a>.en_US
dc.identifier.citationNakata, M., Ågmo, A., Satoshi, S. & Ogawa, S. (2018). The Role of Estrogen Receptor beta (ER beta) in the Establishment of Hierarchical Social Relationships in Male Mice. <i>Frontiers in Behavioral Neuroscience, 12</i>. https://doi.org/10.3389/fnbeh.2018.00245en_US
dc.identifier.cristinIDFRIDAID 1670711
dc.identifier.doi10.3389/fnbeh.2018.00245
dc.identifier.issn1662-5153
dc.identifier.urihttps://hdl.handle.net/10037/15027
dc.language.isoengen_US
dc.publisherNRC Research Pressen_US
dc.relation.journalFrontiers in Behavioral Neuroscience
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.subjectgonadal steroid hormoneen_US
dc.subjecttestosteroneen_US
dc.subjectaggressive behavioren_US
dc.subjectdominance hierarchyen_US
dc.subjectrank determinationen_US
dc.subjectagonistic behavioren_US
dc.subjectsocial interactionen_US
dc.subjecttube testen_US
dc.titleThe Role of Estrogen Receptor β (ERβ) in the Establishment of Hierarchical Social Relationships in Male Miceen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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