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dc.contributor.advisorSeternes, Ole Morten
dc.contributor.authorKaur, Gurjit
dc.date.accessioned2019-06-05T14:10:03Z
dc.date.available2019-06-05T14:10:03Z
dc.date.issued2014-05-20
dc.description.abstractSignal transduction mediated by protein kinases and phosphatases is complex and highly coordinated. The mitogen activated protein kinases (MAPKs) are key components that transduce extracellular stimuli to biological responses by a three-tier module. The biological functions of steroid receptor coactivator-3 (SRC-3), a coactivator of nuclear hormone receptors and numerous transcription factors, is regulated by multiple pathways involving the MAP kinase signaling cascades. The oncogenic SRC-3 protein is found to be overexpressed in multiple human cancers, such as breast, prostate and lung cancer, and is implicated in the regulation of multiple physiological and pathological functions. The upstream kinase of SRC-3 phosphorylation at S857 in vivo has yet to be found, although ERK3 has been reported to phosphorylate this site. Here, we investigate the association of the ERK3-MK5 pathway with SRC-3 phosphorylation at S857 residue in the human lung cancer cells H1299.en_US
dc.identifier.urihttps://hdl.handle.net/10037/15446
dc.language.isoengen_US
dc.publisherUiT Norges arktiske universiteten_US
dc.publisherUiT The Arctic University of Norwayen_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2014 The Author(s)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0en_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)en_US
dc.subject.courseIDFAR-3901en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.titleIdentifying signaling pathway responsible for SRC-3 serine 857 phosphorylation. A study in lung cancer cellsen_US
dc.typeMaster thesisen_US
dc.typeMastergradsoppgaveen_US


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Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0)