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dc.contributor.advisorVåbenø, Jon
dc.contributor.advisorStrøm, Morten Bøhmer
dc.contributor.authorEriksen, Øystein
dc.date.accessioned2008-08-20T11:49:26Z
dc.date.available2008-08-20T11:49:26Z
dc.date.issued2008-06-16
dc.description.abstractCXCR4 is a GPCR that by activation of its ligand CXCL12 is involved in the pathology of several diseases, examples being cancer and rheumatoid arthritis. It has also shown to play a crucial role for HIV-1 entry into T-cells and the development of AIDS. Several cyclopentapeptides (CPPs) based on the sequence D-Tyr-Arg-Arg-2-Nal-Gly of the lead compound FC131 have shown to have antagonistic activity. These CCPs are therefore targets for drug research. In this thesis a previously published 3-point pharmacophore for these CCPs is reproduced and a new 4-point pharmacophore is presented. Structural similarities of low-energy conformations of CPPs that fit these pharmacophores have been identified. A set of new conformational stabilized CPPs based on these findings have been designed and synthesized. A set of citrulline based analogs of FC131 have been synthesized as they will serve as probes to determine the nature of the Arg residues interaction with CXCR4en
dc.format.extent2189013 bytes
dc.format.extent2066 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.identifier.urihttps://hdl.handle.net/10037/1580
dc.identifier.urnURN:NBN:no-uit_munin_1355
dc.language.isoengen
dc.publisherUniversitetet i Tromsøen
dc.publisherUniversity of Tromsøen
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2008 The Author(s)
dc.subject.courseIDFAR-3901nor
dc.subjectVDP::Matematikk og naturvitenskap: 400::Kjemi: 440::Legemiddelkjemi: 448en
dc.titleDesign and synthesis of novel cyclopentapeptide antagonist for the chemokine receptor CXCR4en
dc.typeMaster thesisen
dc.typeMastergradsoppgaveen


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