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dc.contributor.authorSiljan, William Ward
dc.contributor.authorHolter, Jan Cato
dc.contributor.authorMichelsen, Annika
dc.contributor.authorNymo, Stig Haugset
dc.contributor.authorLauritzen, Trine
dc.contributor.authorOppen, Kjersti
dc.contributor.authorHusebye, Einar
dc.contributor.authorUeland, Thor
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorAukrust, Pål
dc.contributor.authorHeggelund, Lars
dc.date.accessioned2019-08-05T11:28:01Z
dc.date.available2019-08-05T11:28:01Z
dc.date.issued2019
dc.description.abstract<b>Background</b><br> Biomarkers may facilitate clinical decisions in order to guide antimicrobial treatment and prediction of prognosis in community-acquired pneumonia (CAP). We measured serum C-reactive protein, procalcitonin (PCT) and calprotectin levels, and plasma pentraxin 3 (PTX3) and presepsin levels, along with whole-blood white cell counts, at three time-points, and examined their association with microbial aetiology and adverse clinical outcomes in CAP.<br> <b>Methods</b><br> Blood samples were obtained at hospital admission, clinical stabilisation and 6-week follow-up from 267 hospitalised adults with CAP. Adverse short-term outcome was defined as intensive care unit admission and 30-day mortality. Long-term outcome was evaluated as 5-year all-cause mortality.<br> <b>Results</b><br> Peak levels of all biomarkers were seen at hospital admission. Increased admission levels of C-reactive protein, PCT and calprotectin were associated with bacterial aetiology of CAP, while increased admission levels of PCT, PTX3 and presepsin were associated with adverse short-term outcome. In univariate and multivariate regression models, white blood cells and calprotectin at 6-week follow-up were predictors of 5-year all-cause mortality.<br> <b>Conclusions</b><br> Calprotectin emerges as both a potential early marker of bacterial aetiology and a predictor for 5-year all-cause mortality in CAP, whereas PCT, PTX3 and presepsin may predict short-term outcome.en_US
dc.description.sponsorshipThis work was supported by Vestre Viken Hospital Trust, Norway. The funder had no role in study design, data collection and analysis, decision to publish or preparation of the manuscripten_US
dc.descriptionPublished version, available at <a href=http://dx.doi.org/10.1183/23120541.00014-2019>http://dx.doi.org/10.1183/23120541.00014-2019</a>en_US
dc.identifier.citationSiljan, W., Holter, J.C., Michelsen, A., Nymo, S.H., Lauritzen, T., Oppen, K., Husebye E., Ueland, T., Mollnes, T.E., Aukrust, P., Heggelund, L. (2019) Inflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: results of a 5-year follow-up cohort study. <i>ERS Monograph, 5</i>, (1), 1-10. http://dx.doi.org/10.1183/23120541.00014-2019en_US
dc.identifier.cristinIDFRIDAID 1708047
dc.identifier.doi10.1183/23120541.00014-2019
dc.identifier.issn2312-508X
dc.identifier.issn2312-5098
dc.identifier.urihttps://hdl.handle.net/10037/15841
dc.language.isoengen_US
dc.publisherEuropean Respiratory Society (ERS)en_US
dc.relation.journalERS Monograph
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.titleInflammatory biomarkers are associated with aetiology and predict outcomes in community-acquired pneumonia: Results of a 5-year follow-up cohort studyen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US


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