Vis enkel innførsel

dc.contributor.authorHagberg, Guri
dc.contributor.authorFure, Brynjar
dc.contributor.authorSandset, Else Charlotte
dc.contributor.authorThommessen, Bente
dc.contributor.authorIhle-Hansen, Håkon
dc.contributor.authorØksengård, Anne Rita
dc.contributor.authorNygård, Ståle
dc.contributor.authorWyller, Torgeir Bruun
dc.contributor.authorIhle-Hansen, Hege
dc.date.accessioned2019-10-09T13:08:54Z
dc.date.available2019-10-09T13:08:54Z
dc.date.issued2019-02-07
dc.description.abstract<p><i>Background - </i>Stroke and coronary heart disease share the same risk factors, and a multifactorial intervention after stroke may potentially result in the same reduction in cardiovascular mortality as seen after coronary events. We aimed to evaluate the effect on survival 7 years after a 1-year multifactorial risk factor intervention, and identify clinical predictors for long-term survival in a hospital-based cohort of patients with first-ever stroke or transient ischemic attack (TIA). <p><i>Materials and methods - </i>We performed a secondary analysis of a randomized controlled trial including patients between February 2007 and July 2008 comparing an intensive risk factor intervention vs usual care the first year poststroke to prevent cognitive impairment. From February 2014 to July 2016, all patients were invited to a follow-up. For patients dying throughout the follow-up period, date of death was obtained from the medical record. Examination at baseline and 1-year follow-up included extensive assessment of vascular risk factors and cognitive assessments. <p><i>Results - </i>A total of 195 patients were randomized. Mean (SD) age was 71.6 (12.5) years, 53.3% were male, mean (SD) body mass index (BMI) was 25.6 (4.1) kg/m². During follow-up, 35 patients in the intervention group and 41 in the control group died. Kaplan–Meier survival estimates show no significant difference in intention-to-treat (ITT) population or complete case (CC) population (log-rank <i>P</i>=0.29 vs log-rank <i>P</i>=0.07). In multivariable Cox proportional hazards regression analyses, lower age and higher BMI was independently associated with long-term survival, adjusted HR (95% CI) 1.08 (1.05–1.11) per year and 0.91 (0.85–0.97) per kg/m². <p><i>Conclusion - </i>In this post hoc analysis, we found no significant effect on survival after 7 years of a multifactorial risk factor program given during the first year after first-ever stroke or TIA. Higher BMI was an independent predictor for long-term survival in this cohort.en_US
dc.descriptionSource at <a href=https://doi.org/10.2147/VHRM.S191873>https://doi.org/10.2147/VHRM.S191873</a>.en_US
dc.identifier.citationHagberg, G., Fure, B., Sandset, E.C., Thommessen, B., Ihle-Hansen, H., Øksengård, A.R., ... Ihle-Hansen, H. (2019). Long-term effects on survival after a 1-year multifactorial vascular risk factor intervention after stroke or TIA: secondary analysis of a randomized controlled trial, a 7-year follow-up study. <i>Vascular Health and Risk Management, 15</i>, 11-18. https://doi.org/10.2147/VHRM.S191873en_US
dc.identifier.cristinIDFRIDAID 1702240
dc.identifier.doi10.2147/VHRM.S191873
dc.identifier.issn1178-2048
dc.identifier.urihttps://hdl.handle.net/10037/16367
dc.language.isoengen_US
dc.publisherDove Medical Pressen_US
dc.relation.journalVascular Health and Risk Management
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.subjectRCTen_US
dc.subjectstrokeen_US
dc.subjectcardiovascular risken_US
dc.subjectrisk factor managementen_US
dc.subjectsecondary preventionen_US
dc.titleLong-term effects on survival after a 1-year multifactorial vascular risk factor intervention after stroke or TIA: secondary analysis of a randomized controlled trial, a 7-year follow-up studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel