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dc.contributor.authorZhang, Zuobing
dc.contributor.authorChi, Heng
dc.contributor.authorDalmo, Roy Ambli
dc.date.accessioned2019-10-15T09:32:36Z
dc.date.available2019-10-15T09:32:36Z
dc.date.issued2019-01-25
dc.description.abstractThe general understanding has been that only adaptive immunity is capable of immunological memory, but this concept has been challenged in recent years by studies showing that innate immune systems can mount resistance to reinfection—as the innate immune system can adapt its function following an insult. Innate immune training offers an attractive approach in intensive fish larval rearing, especially since the adaptive immune system is not fully developed. Trained innate immunity will potentially favor robust fish in terms of resistance to viral and bacterial diseases. So-called immunostimulants such as ß-glucans have for decades been used both in laboratories and in intensive fish aquaculture. Treatment of fish by ß-glucans (and by other substances with pathogen-associated molecular patterns) often induces activation of non-specific/innate immune mechanisms and induces higher disease resistance. The reported effects of e.g., ß-glucans fit nicely into the concept “trained innate immunity,” but the research on fish does not yet include analysis of epigenetic changes that may be a prerequisite for long-lasting trained innate immunity. In this “perspective,” we will discuss how in practical terms and based on prior knowledge one can introduce innate immune training in brood stock fish, and their offspring, and whether innate immune training by ß-glucans is a viable approach in larval aquaculture.en_US
dc.description.sponsorshipUiT The Arctic University of Norway Open Access publication Fund Tromsø Research Foundationen_US
dc.descriptionSource at <a href=https://doi.org/10.3389/fimmu.2019.00042>https://doi.org/10.3389/fimmu.2019.00042</a>.en_US
dc.identifier.citationZhang, Z., Chi, H. & Dalmo, R.A. (2019). Trained Innate Immunity of Fish Is a Viable Approach in Larval Aquaculture. <i>Frontiers in Immunology, 10</i>, 42. https://doi.org/10.3389/fimmu.2019.00042en_US
dc.identifier.cristinIDFRIDAID 1692725
dc.identifier.doi10.3389/fimmu.2019.00042
dc.identifier.issn1664-3224
dc.identifier.urihttps://hdl.handle.net/10037/16402
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Immunology
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/HAVBRUK2/237315/Norway/Fish Virus Vaccines/ViVaFish/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/NANO2021/239140/Norway/Nanoparticle encapsulation of plant-based vaccine against piscine reovirus infection in salmon//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470::Genetics and genomics: 474en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474en_US
dc.subjectVDP::Agriculture and fishery disciplines: 900::Fisheries science: 920::Fish health: 923en_US
dc.subjectVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920::Fiskehelse: 923en_US
dc.subjecttrained innate immunityen_US
dc.subjectaquacultureen_US
dc.subjectfishen_US
dc.subjectbeta-glucanen_US
dc.subjectfish larvaeen_US
dc.titleTrained Innate Immunity of Fish Is a Viable Approach in Larval Aquacultureen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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