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dc.contributor.authorHolte, Kari
dc.contributor.authorErsdal, Hege Langli
dc.contributor.authorEilevstjønn, Joar
dc.contributor.authorThallinger, Monica
dc.contributor.authorLinde, Jørgen Erland
dc.contributor.authorKlingenberg, Claus
dc.contributor.authorHolst, René
dc.contributor.authorJatosh, Samwel
dc.contributor.authorKidanto, Hussein
dc.contributor.authorStordal, Ketil
dc.date.accessioned2019-10-28T10:04:14Z
dc.date.available2019-10-28T10:04:14Z
dc.date.issued2019-09-26
dc.description.abstract<p><i>Background - </i>Expired carbon dioxide (ECO<sub>2</sub>) indicates degree of lung aeration immediately after birth. Favourable ventilation techniques may be associated with higher ECO<sub>2</sub> and a faster increase. Clinical condition will however also affect measured values. The aim of this study was to explore the relative impact of ventilation factors and clinical factors on ECO<sub>2</sub> during bag-mask ventilation of near-term newborns. <p><i>Methods - </i>Observational study performed in a Tanzanian rural hospital. Side-stream measures of ECO<sub>2</sub>, ventilation data, heart rate and clinical information were recorded in 434 bag-mask ventilated newborns with initial heart rate <120 beats per minute. We studied ECO<sub>2</sub> by clinical factors (birth weight, Apgar scores and initial heart rate) and ventilation factors (expired tidal volume, ventilation frequency, mask leak and inflation pressure) in random intercept models and Cox regression for time to ECO<sub>2</sub> >2%. <p><i>Results - </i>ECO<sub>2</sub> rose non-linearly with increasing expired tidal volume up to >10 mL/kg, and sufficient tidal volume was critical for the time to reach ECO<sub>2</sub> >2%. Ventilation frequency around 30/min was associated with the highest ECO<sub>2</sub>. Higher birth weight, Apgar scores and initial heart rate were weak, but significant predictors for higher ECO<sub>2</sub>. Ventilation factors explained 31% of the variation in ECO<sub>2</sub> compared with 11% for clinical factors. <p><i>Conclusions - </i>Our findings indicate that higher tidal volumes than currently recommended and a low ventilation frequency around 30/min are associated with improved lung aeration during newborn resuscitation. Low ECO<sub>2</sub> may be used to identify unfavourable ventilation technique. Clinical factors are also associated with persistently low ECO<sub>2</sub> and must be accounted for in the interpretation.en_US
dc.descriptionSource at <a href=https://doi.org/10.1136/bmjpo-2019-000544>https://doi.org/10.1136/bmjpo-2019-000544</a>.en_US
dc.identifier.citationHolte, K., Ersdal, H.L., Eilevstjønn, J., Thallinger, M., Linde, J., Klingenberg, C., ... Stordal, K. (2019). Predictors fpr expired CO<sub>2</sub> in neonatal bag-mask ventilation at birth: observational study. <i>BMJ Paediatrics Open, 3</i>, e000544. 2019https://doi.org/10.1136/bmjpo-2019-000544en_US
dc.identifier.cristinIDFRIDAID 1733291
dc.identifier.doi10.1136/bmjpo-2019-000544
dc.identifier.issn2399-9772
dc.identifier.urihttps://hdl.handle.net/10037/16486
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.journalBMJ Paediatrics Open
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/GLOBVAC/228203/Norway/Safer Births- new knowledge and innovations to decrease perinatal mortality and morbidity worldwide//en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Pediatrics: 760en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Pediatri: 760en_US
dc.titlePredictors fpr expired CO2 in neonatal bag-mask ventilation at birth: observational studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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