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dc.contributor.authorBorgen, Tove Tveitan
dc.contributor.authorBjørnerem, Åshild
dc.contributor.authorSolberg, Lene Bergendal
dc.contributor.authorAndreasen, Camilla
dc.contributor.authorBrunborg, Cathrine
dc.contributor.authorStenbro, May-Britt
dc.contributor.authorHübschle, Lars Michael
dc.contributor.authorFroholdt, Anne
dc.contributor.authorFigved, Wender
dc.contributor.authorApalset, Ellen M
dc.contributor.authorGjertsen, Jan-Erik
dc.contributor.authorBasso, Trude
dc.contributor.authorLund, Ida
dc.contributor.authorHansen, Ann Kristin
dc.contributor.authorStutzer, Jens-Meinhard
dc.contributor.authorDahl, Cecilie
dc.contributor.authorOmsland, Tone Kristin
dc.contributor.authorNordsletten, Lars
dc.contributor.authorFrihagen, Frede Jon
dc.contributor.authorEriksen, Erik Fink
dc.date.accessioned2019-10-28T19:27:06Z
dc.date.available2019-10-28T19:27:06Z
dc.date.issued2019-02-08
dc.description.abstract<p><i>Purpose - </i>Norway has among the highest incidence rates of fractures in the world. Vertebral fracture assessment (VFA) and trabecular bone score (TBS) provide information about fracture risk, but their importance have not been studied in Norwegian patients with fragility fractures. The objectives of this study were to examine the clinical characteristics of a cohort of women and men with fragility fractures, their prevalence of vertebral fractures using VFA and prevalence of low TBS, and explore the differences between the sexes and patients with and without vertebral fractures. <p><i>Methods - </i>This cross-sectional sub-study of the Norwegian Capture the Fracture Initiative (NoFRACT) included 839 patients with fragility fractures. Of these, 804 patients had bone mineral density (BMD) of the total hip, femoral neck and/or spine assessed using dual energy x-ray absorptiometry, 679 underwent concomitant VFA, 771 had TBS calculated and 696 responded to a questionnaire. <p><i>Results - </i>Mean age was 65.8 (SD 8.8) years and 80.5% were women. VFA revealed vertebral fractures in 34.8% of the patients and 34.0% had low TBS (≤ 1.23), with no differences between the sexes. In all patients with valid measures of both VFA and TBS, 53.8% had either vertebral fractures, low TBS, or both. In the patients with osteopenia at the femoral neck, 53.6% had either vertebral fractures, low TBS, or both. Femoral neck BMD T-score ≤ −2.5 was found in 13.8% of all patients, whereas the corresponding figure was 27.4% using the skeletal site with lowest T-score. Women exhibited lower BMD at all sites and lower TBS than men (1.27 vs. 1.29), (all p < 0.05). Patients with prevalent vertebral fractures were older (69.4 vs. 64.0 years), exhibited lower BMD at all sites and lower TBS (1.25 vs.1.29) than those without vertebral fractures (all p < 0.05). Before assessment, 8.2% were taking anti-osteoporotic drugs (AOD), and after assessment, the prescription rate increased to 56.2%. <p><i>Conclusions - </i>More than half of the patients with fragility fractures had vertebral fractures, low TBS or both. The prescription of AOD increased seven fold from before assessment to after assessment, emphasizing the importance of risk assessment after a fragility fracture.en_US
dc.description.sponsorshipRegional Health Authorities, Norway North Norwegian Health Authorities Vestre Viken Hospital Trusten_US
dc.descriptionSource at <a href=https://doi.org/10.1016/j.bone.2019.02.008>https://doi.org/10.1016/j.bone.2019.02.008</a>.en_US
dc.identifier.citationBorgen, T.T., Bjørnerem, Å., Solberg, L.B., Andreasen, C., Brunborg, C., Stenbro, M.B.... Eriksen, E.F. (2019). High prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACT. <i>Bone, 122</i>, 14-21. https://doi.org/10.1016/j.bone.2019.02.008en_US
dc.identifier.cristinIDFRIDAID 1698932
dc.identifier.doi10.1016/j.bone.2019.02.008
dc.identifier.issn8756-3282
dc.identifier.issn1873-2763
dc.identifier.urihttps://hdl.handle.net/10037/16496
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalBone
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.subjectBone mineral densityen_US
dc.subjectFracture risken_US
dc.subjectOsteoporosisen_US
dc.subjectTrabecular bone scoreen_US
dc.subjectVertebral fracture assessmenten_US
dc.subjectVertebral fracturesen_US
dc.titleHigh prevalence of vertebral fractures and low trabecular bone score in patients with fragility fractures: A cross-sectional sub-study of NoFRACTen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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