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dc.contributor.authorSun, Yi-Qian
dc.contributor.authorBrumpton, Ben Michael
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorChen, Yue
dc.contributor.authorKvaløy, Kirsti
dc.contributor.authorMai, Xiao-Mei
dc.date.accessioned2019-10-29T11:59:49Z
dc.date.available2019-10-29T11:59:49Z
dc.date.issued2019-10-14
dc.description.abstract<i>Background</i> - We aimed to investigate the potential causal associations of adiposity with asthma overall, asthma by atopic status or by levels of symptom control in a large adult population and stratified by sex. We also investigated the potential for reverse causation between asthma and risk of adiposity.<p> <p><i>Methods</i> - We performed a bidirectional one-sample Mendelian randomisation (MR) study using the Norwegian Nord-Trøndelag Health Study population including 56 105 adults. 73 and 47 genetic variants were included as instrumental variables for body mass index (BMI) and waist-to-hip ratio (WHR), respectively. Asthma was defined as ever asthma, doctor-diagnosed asthma and doctor-diagnosed active asthma, and was further classified by atopic status or levels of symptom control. Causal OR was calculated with the Wald method.<p> <p><i>Results</i> - The ORs per 1 SD (4.1 kg/m2) increase in genetically determined BMI were ranged from 1.36 to 1.49 for the three asthma definitions and similar for women and men. The corresponding ORs for non-atopic asthma (range 1.42–1.72) appeared stronger than those for the atopic asthma (range 1.18–1.26), but they were similar for controlled versus partly controlled doctor-diagnosed active asthma (1.43 vs 1.44). There was no clear association between genetically predicted WHR and asthma risk or between genetically predicted asthma and the adiposity markers.<p> <p><i>Conclusions</i> - Our MR study provided evidence of a causal association of BMI with asthma in adults, particularly with non-atopic asthma. There was no clear evidence of a causal link between WHR and asthma or of reverse causation.en_US
dc.descriptionThis article has been accepted for publication in <i>Thorax</i>, 2019 following peer review, and the Version of Record can be accessed online at <a href=http://dx.doi.org/10.1136/thoraxjnl-2019-213678>http://dx.doi.org/10.1136/thoraxjnl-2019-213678. </a><p> © Authors (or their employer(s))en_US
dc.identifier.citationSun, Y-Q., Brumpton, B.M., Langhammer, A., Chen, Y., Kvaløy, K. & Mai, X-M. (2019). Adiposity and asthma in adults: a bidirectional Mendelian randomization analysis of the HUNT Study. <i>Thorax, 0</i>:1-7. http://dx.doi.org/10.1136/thoraxjnl-2019-213678en_US
dc.identifier.cristinIDFRIDAID 1741275
dc.identifier.issn0040-6376
dc.identifier.issn1468-3296
dc.identifier.urihttps://hdl.handle.net/10037/16505
dc.language.isoengen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.journalThorax
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/?/?/Norway/?/?/en_US
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801en_US
dc.titleAdiposity and asthma in adults: a bidirectional Mendelian randomization analysis of the HUNT Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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