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dc.contributor.advisorFlach, Carl-Fredrik
dc.contributor.advisorE. Sollid, Johanna
dc.contributor.authorLea, Ingrid
dc.date.accessioned2008-11-06T13:40:52Z
dc.date.available2008-11-06T13:40:52Z
dc.date.issued2008-06-01
dc.description.abstractHelicobacter pylori is a Gram-negative flagellated bacterium that infects the stomach of around 50 % of the worlds population, and can give rise to serious disease such as chronic gastritis, duodenal ulcer and stomach cancer. The current treatment against H. pylori, consisting of a combination of a proton pump inhibitor and two different antibiotics, is effective but has several drawbacks such as increased risk of antibiotic resistance and no protection against re-infection. Although extensive research is going on to develop a vaccine that would be an attractive alternative or complement to the current treatment, there is no vaccine available against H. pylori today. Antibodies to a number of antigens have been detected in the sera of infected patients, and many of these are known to be virulence factors, and are considered as candidate H. pylori vaccine antigens, alone or in a combination. Two such antigens are Neutrophil-activating protein (NAP) and Flagellin A (FlaA). In this project the H. pylori antigens NAP and FlaA were cloned and expressed in E. coli, and a purification strategy were set up for the two proteins.en
dc.format.extent5971121 bytes
dc.format.extent387119 bytes
dc.format.extent2060 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.identifier.urihttps://hdl.handle.net/10037/1650
dc.identifier.urnURN:NBN:no-uit_munin_1413
dc.language.isoengen
dc.publisherUniversitetet i Tromsøen
dc.publisherUniversity of Tromsøen
dc.rights.accessRightsopenAccess
dc.rights.holderCopyright 2008 The Author(s)
dc.subject.courseIDBIO-3941nor
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470::Genetics and genomics: 474en
dc.subjectvaccine candidate antigensen
dc.subjectHelicobacter pylorien
dc.subjectprotein purificationen
dc.titlePurification of the recombinantly produced Helicobacter pylori antigens NAP and FlaAen
dc.typeMaster thesisen
dc.typeMastergradsoppgaveen


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