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dc.contributor.authorMoritz, Steffen
dc.contributor.authorSchmidt, Stefanie
dc.contributor.authorLüdtke, Thies
dc.contributor.authorBraunschneider, Lea-Elena
dc.contributor.authorManske, Alisa
dc.contributor.authorSchneider, Brooke C.
dc.contributor.authorVeckenstedt, Ruth
dc.date.accessioned2019-11-12T07:18:57Z
dc.date.available2019-11-12T07:18:57Z
dc.date.issued2019-07-20
dc.description.abstractTo mitigate the often chronic course of schizophrenia and improve functional outcome, researchers are increasingly interested in prodromal states and psychological risk factors that may predict the outbreak of psychotic symptoms, but are also amenable to change. In recent years, depressive symptoms have been proposed as precursors of psychosis and some interventional studies indicate that the amelioration of depressive symptoms and depression-related thinking styles (e.g., worrying) improves positive symptoms, thereby “killing two birds with one stone”. Yet, in a prior study, we were unable to find a strong specific predictive role of depression on paranoia over three years, which may have been due to the use of a nonclinical sample with minimal/mild symptom fluctuations. To address this further, in the present study we adopted a similar methodological approach but assessed a large patient sample with a schizophrenia spectrum disorder at three assessment points; baseline (N = 250), 6 weeks later (n = 207, 82.8% retention) and 6 months after baseline (n = 185, 74% retention). Using cross-lagged modeling, we assessed paranoia with the respective items from the Positive and Negative Syndrome Scale (PANSS) and the Psychosis Rating Scales (PSYRATS) delusions subscale. Depression was measured using the Patient Health Questionnaire-9 (PHQ-9) and the Calgary Depression Scale for Schizophrenia (CDSS). We could identify a significant pathway from depression to paranoia from baseline to post (negative association) but not from post to follow-up. Paranoia significantly predicted depressive symptoms for both intervals. Our findings do not refute claims that depression may precede or even predict psychosis, but such a linkage does not seem to be ubiquitous.en_US
dc.descriptionAccepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/>CC BY-NC-ND 4.0. </a>Final version published in <i>Schizophrenia Research, 211</i>, 79-85, is available at <a href=https://doi.org/10.1016/j.schres.2019.06.022>https://doi.org/10.1016/j.schres.2019.06.022. </a>en_US
dc.identifier.citationMoritz, S., Schmidt, S., Lüdtke, T., Braunschneider, L.-E., Manske, A., Schneider, B.C. & Veckenstedt, R. (2019). Post-psychotic depression: Paranoia and the damage done. <i>Schizophrenia Research, 211</i>, 79-85. https://doi.org/10.1016/j.schres.2019.06.022en_US
dc.identifier.cristinIDFRIDAID 1731303
dc.identifier.doi10.1016/j.schres.2019.06.022
dc.identifier.issn0920-9964
dc.identifier.issn1573-2509
dc.identifier.urihttps://hdl.handle.net/10037/16649
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalSchizophrenia Research
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.titlePost-psychotic depression: Paranoia and the damage doneen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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