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dc.contributor.authorHolmen, Tom Langerud
dc.contributor.authorEgeland, Jens
dc.contributor.authorAndersen, Eivind
dc.contributor.authorMordal, Jon
dc.contributor.authorAndreassen, Ole Andreas
dc.contributor.authorUeland, Thor
dc.contributor.authorBigseth, Therese Torgersen
dc.contributor.authorBang-Kittilsen, Gry
dc.contributor.authorEngh, John
dc.date.accessioned2019-12-02T13:48:28Z
dc.date.available2019-12-02T13:48:28Z
dc.date.issued2019-10-25
dc.description.abstract<i>Objective</i>: We investigated whether levels of current physical activity (PA) contribute to the established relationship between cardiorespiratory fitness (CRF) and cognition in schizophrenia and whether brain-derived neurotrophic factor (BDNF) or its precursor proBDNF mediates this relationship. <p> <p><i>Method</i>: Sixty-one outpatients with schizophrenia spectrum disorders participated. Neurocognition was assessed with the Wechsler Adult Intelligence Scale (WAIS) and nine subtests from the MATRICS battery comprising a neurocognitive composite score (NCS). CRF was assessed with peak oxygen uptake (VO2peak) measured directly during a maximum exercise test. Current PA levels were objectively assessed by an accelerometer worn for four consecutive days. BDNF and proBDNF were measured in fasting blood. Four serial parallel mediation analyses and two additional parallel mediation analyses were conducted, while controlling for age and sex at all levels. <p> <p><i>Results</i>: No direct effects were found between PA measures and WAIS or NCS. No significant mediating effects of CRF or BDNF/proBDNF were detected. <p> <p><i>Conclusion</i>: The results do not support the hypothesis that PA contributes to the naturally occurring relationship between CRF and cognition in schizophrenia or the hypothesis that BDNF or proBDNF mediates this relationship. The results arguably support the assumption that the association between CRF and cognition in schizophrenia is established developmentally early.en_US
dc.descriptionSource at <a href=https://doi.org/10.3389/fpsyt.2019.00785>https://doi.org/10.3389/fpsyt.2019.00785. </a>en_US
dc.identifier.citationHolmen TL, Egeland J, Andersen E, Mordal J, Andreassen OA, Ueland T, Bigseth T, Bang-Kittilsen G, Engh J. The Association Between Cardiorespiratory Fitness and Cognition Appears Neither Related to Current Physical Activity Nor Mediated by Brain-Derived Neurotrophic Factor in a Sample of Outpatients With Schizophrenia . Frontiers in Psychiatry. 2019en_US
dc.identifier.cristinIDFRIDAID 1750545
dc.identifier.doihttps://doi.org/10.3389/fpsyt.2019.00785
dc.identifier.issn1664-0640
dc.identifier.urihttps://hdl.handle.net/10037/16765
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers in Psychiatry
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Social science: 200::Psychology: 260en_US
dc.subjectVDP::Samfunnsvitenskap: 200::Psykologi: 260en_US
dc.titleThe Association Between Cardiorespiratory Fitness and Cognition Appears Neither Related to Current Physical Activity Nor Mediated by Brain-Derived Neurotrophic Factor in a Sample of Outpatients With Schizophreniaen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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