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dc.contributor.authorMadut, Nuol Aywel
dc.contributor.authorMuleme, James
dc.contributor.authorKankya, Clovice
dc.contributor.authorNasinyama, George William
dc.contributor.authorMuma, John Bwalya
dc.contributor.authorGodfroid, Jacques
dc.contributor.authorJubara, Ambrose Samuel
dc.contributor.authorMuwonge, Adrian
dc.date.accessioned2019-12-09T14:13:15Z
dc.date.available2019-12-09T14:13:15Z
dc.date.issued2019-06-26
dc.description.abstract<p><i>Background - </i>In this study, we focused on three zoonotic brucellosis risk groups; abattoir workers, febrile cases at Wau hospital and cattle herders, in Bahr el Ghazal region, South Sudan. Competitive c-ELISA was used to detect anti-<i>Brucella</i> antibodies in 725 individuals between December 2015 and May 2016. In addition, questionnaire metadata, focus group discussions and key informant interviews were used to characterize the epidemiology of zoonotic brucellosis in this region. <p><i>Results - </i>Overall, we estimate 27.2 % (95% CI = 23.9–30.6) brucellosis sero-prevalence; 32.1% (95% CI = 26.2–38.4), 23.0% (95% CI = 19.1–27.4) and 34.6% (95% CI = 24.4–46.3) among abattoir workers, febrile cases, and herders, respectively. Marital status (Single, OR = 0.58, 95%CI: 0.36–0.91, <i>P</i> = 0.02) and ethnicity (Kerash OR = 6.01, 95%CI: 1.97–21.10, <i>P</i> = 0.003 and Balanda, OR = 3.78, 95%CI: 1.42–12.02, <i>P</i> = 0.01) were associated with brucellosis. While gender and ethnicity were important factors for general awareness of zoonotic diseases. Highly ranked occupations at risk included veterinarian, butchers and milk handlers. We also identified covariate patterns for clinical diagnostics and public health interventions. <p><i>Conclusion - </i>We report the highest sero-prevalence of zoonotic brucellosis in three risk groups in the East African region. All this is not only occurring in a population with limited awareness that brucellosis is a zoonotic disease but also where one in nine health workers tested was sero-positive. We identified social demographic associations with brucellosis, however, the qualitative analysis suggests these are more complex and nuanced. Therefore, future studies could benefit from the use of the mixed methods approach to add extensiveness and depth to our understanding of zoonotic disease drivers, in order to implement mitigating measures such as cattle vaccination.en_US
dc.identifier.citationMadut NA, Muleme J, Kankya C, Nasinyama GW, Muma J, Godfroid J, Jubara AS, Muwonge A. The epidemiology of zoonotic brucellosis in Bahr el Ghazal region of South Sudan. Frontiers In Public Health. 2019;7en_US
dc.identifier.cristinIDFRIDAID 1737710
dc.identifier.doi10.3389/fpubh.2019.00156
dc.identifier.issn2296-2565
dc.identifier.urihttps://hdl.handle.net/10037/16854
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.journalFrontiers In Public Health
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480::Parasitology: 484en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Parasittologi: 484en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Epidemiology medical and dental statistics: 803en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803en_US
dc.titleThe epidemiology of zoonotic brucellosis in Bahr el Ghazal region of South Sudanen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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