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dc.contributor.authorDahle, Maria
dc.contributor.authorJørgensen, Jorunn B
dc.date.accessioned2019-12-17T14:19:29Z
dc.date.available2019-12-17T14:19:29Z
dc.date.issued2019-01-30
dc.description.abstractViral diseases represent one of the major threats for salmonid aquaculture. Survival from viral infections are highly dependent on host innate antiviral immune defense, where interferons are of crucial importance. Neutralizing antibodies and T cell effector mechanisms mediate long-term antiviral protection. Despite an immune cell repertoire comparable to higher vertebrates, farmed fish often fail to mount optimal antiviral protection. In the quest to multiply and spread, viruses utilize a variety of strategies to evade or escape the host immune system. Understanding the specific interplay between viruses and host immunity at depth is crucial for developing successful vaccination and treatment strategies in mammals. However, this knowledge base is still limited for pathogenic fish viruses. Here, we have focused on five RNA viruses with major impact on salmonid aquaculture: Salmonid alphavirus, Infectious salmon anemia virus, Infectious pancreatic necrosis virus, Piscine orthoreovirus and Piscine myocarditis virus. This review explore the protective immune responses that salmonids mount to these viruses and the existing knowledge on how the viruses counteract and/or bypass the immune response, including their IFN antagonizing effects and their mechanisms to establish persisting infections.en_US
dc.identifier.citationDahle MK, Jørgensen JB. Antiviral defense in salmonids – Mission made possible?. Fish and Shellfish Immunology. 2019;87:421-437en_US
dc.identifier.cristinIDFRIDAID 1677455
dc.identifier.doi10.1016/j.fsi.2019.01.043
dc.identifier.issn1050-4648
dc.identifier.issn1095-9947
dc.identifier.urihttps://hdl.handle.net/10037/16956
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalFish and Shellfish Immunology
dc.relation.projectIDNorges forskningsråd: 237315en_US
dc.relation.projectIDNorges forskningsråd: 280847en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/HAVBRUK2/237315/Norway/Fish Virus Vaccines/ViVaFish/en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/HAVBRUK2/280847/Norway/Comparing the protection of attenuated and inactivated virus vaccines against pancreas disease and heart and skeletal muscle inflammation//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)
dc.subjectVDP::Agriculture and fishery disciplines: 900::Fisheries science: 920en_US
dc.subjectVDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920en_US
dc.titleAntiviral defense in salmonids – Mission made possible?en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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