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dc.contributor.authorPaulsen, Else Quist
dc.contributor.authorOrmaasen, Vidar
dc.contributor.authorKran, Anne-Marte Bakken
dc.contributor.authorDunlop, Oona Borghild
dc.contributor.authorUeland, Per Magne
dc.contributor.authorUeland, Thor
dc.contributor.authorEikeland, Randi
dc.contributor.authorAukrust, Pål
dc.contributor.authorNordenmark, Tonje Haug
dc.date.accessioned2019-12-20T15:03:18Z
dc.date.available2019-12-20T15:03:18Z
dc.date.issued2019-11-06
dc.description.abstractFor those surviving encephalitis, the influence on daily life of patients and their relatives may be substantial. In contrast, the prognosis after aseptic meningitis (ASM) is considered good. In this prospective study in patients with encephalitis (n = 20) and ASM (n = 46), we show that both groups experienced reduced Health Related Quality of Life (HRQoL) at two months after discharge, and that workability was reduced in 37% of the patients with ASM. However, 12 months after discharge no neuropsychological deficits were detected in the ASM group, whereas patients with encephalitis had lower scores on tests of fine motor and psychomotor skills as well as on learning and memory. We also found that for patients with encephalitis, neopterin, as a marker of Th1 cell induced macrophage activation, and a putatively neurotoxic ratio of the kynurenine pathway (KP) measured during the acute phase was associated with lower HRQoL. Our data show that not only encephalitis, but also ASM has substantial short-term influence on HRQoL and workability. For patients with encephalitis we suggest a link between immune activation and activation of the KP during the acute phase with impaired HRQoL.en_US
dc.identifier.citationPaulsen EL, Ormaasen V, Kran A, Dunlop OB, Ueland PM, Ueland T, Eikeland R, Aukrust P, Nordenmark TH. Encephalitis and aseptic meningitis: short-term and long-term outcome, quality of life and neuropsychological functioning. Scientific Reports. 2019;9:16158:1-9en_US
dc.identifier.cristinIDFRIDAID 1758271
dc.identifier.doi10.1038/s41598-019-52570-2
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/10037/16978
dc.language.isoengen_US
dc.publisherNature Researchen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.rightsAttribution 4.0 International*
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleEncephalitis and aseptic meningitis: short-term and long-term outcome, quality of life and neuropsychological functioningen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International