Show simple item record

dc.contributor.authorTernullo, Selenia
dc.contributor.authorSchulte Werning, Laura
dc.contributor.authorHolsæter, Ann Mari
dc.contributor.authorSkalko-Basnet, Natasa
dc.date.accessioned2020-01-03T13:41:42Z
dc.date.available2020-01-03T13:41:42Z
dc.date.issued2019-12-20
dc.description.abstractA liposomes-in-hydrogel system as an advanced wound dressing for dermal delivery of curcumin was proposed for improved chronic wound therapy. Curcumin, a multitargeting poorly soluble active substance with known beneficial properties for improved wound healing, was incorporated in deformable liposomes to overcome its poor solubility. Chitosan hydrogel served as a vehicle providing superior wound healing properties. The novel system should assure sustained skin delivery of curcumin, and increase its retention at the skin site, utilizing both curcumin and chitosan to improve the therapy outcome. To optimize the properties of the formulation and determine the effect of the liposomal charge on the hydrogel properties, curcumin-containing deformable liposomes (DLs) with neutral (NDLs), cationic (CDLs), and anionic (ADLs) surface properties were incorporated in chitosan hydrogel. The charged DLs affected the hydrogel’s hardness, cohesiveness, and adhesiveness. Importantly, the incorporation of DLs, regardless of their surface charge, in chitosan hydrogel did not decrease the system’s bioadhesion to human skin. Stability testing revealed that the incorporation of CDLs in hydrogel preserved hydrogel´s bioadhesiveness to a higher degree than both NDLs and ADLs. In addition, CDLs-in-hydrogel enabled the most sustained skin penetration of curcumin. The proposed formulation should be further evaluated in a chronic wound model.en_US
dc.identifier.citationTernullo, Schulte Werning, Holsæter, Skalko-Basnet. Curcumin-In-Deformable Liposomes-In-ChitosanHydrogel as a Novel Wound Dressing. Pharmaceutics. 2020en_US
dc.identifier.cristinIDFRIDAID 1764307
dc.identifier.doi10.3390/pharmaceutics12010008
dc.identifier.issn1999-4923
dc.identifier.urihttps://hdl.handle.net/10037/17018
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalPharmaceutics
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleCurcumin-In-Deformable Liposomes-In-ChitosanHydrogel as a Novel Wound Dressingen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record