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dc.contributor.authorStröhl, Florian
dc.contributor.authorOpstad, Ida Sundvor
dc.contributor.authorTinguely, Jean-Claude
dc.contributor.authorDullo, Firehun Tsige
dc.contributor.authorMela, Ioanna
dc.contributor.authorOsterrieth, Johannes W.M
dc.contributor.authorAhluwalia, Balpreet Singh
dc.contributor.authorKaminski, Clemens F.
dc.date.accessioned2020-01-10T10:06:55Z
dc.date.available2020-01-10T10:06:55Z
dc.date.issued2019-08-22
dc.description.abstractLabelfree nanoscopy encompasses optical imaging with resolution in the 100 nm range using visible wavelengths. Here, we present a labelfree nanoscopy method that combines coherent imaging techniques with waveguide microscopy to realize a <i>super-condenser</i> featuring maximally inclined coherent darkfield illumination with artificially stretched wave vectors due to large refractive indices of the employed Si<sub>3</sub>N<sub>4</sub> waveguide material. We produce the required coherent plane wave illumination for Fourier ptychography over imaging areas 400 μm2 in size via adiabatically tapered single-mode waveguides and tackle the overlap constraints of the Fourier ptychography phase retrieval algorithm two-fold: firstly, the directionality of the illumination wave vector is changed sequentially via a multiplexed input structure of the waveguide chip layout and secondly, the wave vector modulus is shortend via step-wise increases of the illumination light wavelength over the visible spectrum. We test the method in simulations and in experiments and provide details on the underlying image formation theory as well as the reconstruction algorithm. While the generated Fourier ptychography reconstructions are found to be prone to image artefacts, an alternative coherent imaging method, rotating coherent scattering microscopy (ROCS), is found to be more robust against artefacts but with less achievable resolution.en_US
dc.identifier.citationStröhl F, Opstad IS, Tinguely J, Dullo FT, Mela, Osterrieth, Ahluwalia BS, Kaminski. Super-condenser enables labelfree nanoscopy. Optics Express. 2019en_US
dc.identifier.cristinIDFRIDAID 1700232
dc.identifier.doi10.1364/OE.27.025280
dc.identifier.issn1094-4087
dc.identifier.urihttps://hdl.handle.net/10037/17057
dc.language.isoengen_US
dc.publisherOptical Society of Americaen_US
dc.relation.journalOptics Express
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7-IDEAS-ERC/336716/EU/High-speed chip-based nanoscopy to discover real-time sub-cellular dynamics/NANOSCOPY/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Technology: 500en_US
dc.subjectVDP::Teknologi: 500en_US
dc.titleSuper-condenser enables labelfree nanoscopyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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