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dc.contributor.authorTotland, Max
dc.contributor.authorRasmussen, Nikoline Lander
dc.contributor.authorKnudsen, Lars Mørland
dc.contributor.authorLeithe, Edward
dc.date.accessioned2020-01-29T07:06:27Z
dc.date.available2020-01-29T07:06:27Z
dc.date.issued2019-09-09
dc.description.abstractGap junctions consist of arrays of intercellular channels that enable adjacent cells to communicate both electrically and metabolically. Gap junctions have a wide diversity of physiological functions, playing critical roles in both excitable and non-excitable tissues. Gap junction channels are formed by integral membrane proteins called connexins. Inherited or acquired alterations in connexins are associated with numerous diseases, including heart failure, neuropathologies, deafness, skin disorders, cataracts and cancer. Gap junctions are highly dynamic structures and by modulating the turnover rate of connexins, cells can rapidly alter the number of gap junction channels at the plasma membrane in response to extracellular or intracellular cues. Increasing evidence suggests that ubiquitination has important roles in the regulation of endoplasmic reticulum-associated degradation of connexins as well as in the modulation of gap junction endocytosis and post-endocytic sorting of connexins to lysosomes. In recent years, researchers have also started to provide insights into the physiological roles of connexin ubiquitination in specific tissue types. This review provides an overview of the advances made in understanding the roles of connexin ubiquitination in the regulation of gap junction intercellular communication and discusses the emerging physiological and pathophysiological implications of these processes.en_US
dc.identifier.citationTotland MZ, Rasmussen NL, Knudsen LM, Leithe E. Regulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implications. Cellular and Molecular Life Sciences (CMLS). 2019:1-19en_US
dc.identifier.cristinIDFRIDAID 1730658
dc.identifier.doi10.1007/s00018-019-03285-0
dc.identifier.issn1420-682X
dc.identifier.issn1420-9071
dc.identifier.urihttps://hdl.handle.net/10037/17248
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalCellular and Molecular Life Sciences (CMLS)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleRegulation of gap junction intercellular communication by connexin ubiquitination: physiological and pathophysiological implicationsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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