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dc.contributor.authorSteigen, Sonja E
dc.contributor.authorSøland, Tine Merete
dc.contributor.authorNginamau, Elisabeth Sivy
dc.contributor.authorLaurvik, Helene
dc.contributor.authorCostea, Daniela-Elena
dc.contributor.authorJohannessen, Anne Christine
dc.contributor.authorJebsen, Peter Wilhelm
dc.contributor.authorBjerkli, Inger-Heidi
dc.contributor.authorUhlin-Hansen, Lars
dc.contributor.authorHadler-Olsen, Elin Synnøve
dc.date.accessioned2020-02-05T11:41:09Z
dc.date.available2020-02-05T11:41:09Z
dc.date.issued2020-01-03
dc.description.abstract<i>Background</i> - Numerous studies have been presented on histological grading of oral squamous cell carcinomas (OSCC) for predicting survival, but uncertainty of their usefulness rises due to discordances of results. A scoring system should be robust and well validated, and intra‐ and interrater agreement can be used as a tool to visualize the strength of reproducibility.<p><p> <i>Methods</i> - Here, we present an intra‐ and inter‐observer study on evaluation of OSCC using some of the most common histopathological parameters. The observers were from different Norwegian university hospitals, and calibration to ensure accuracy was first performed. Percentage of the agreement was calculated for the score made by the individual observer at different times, as well as between pairs of observers.<p><p> <i>Results</i> - The evaluation made by the same observer at two different time points (intrarater) correlated better than observations made by different participants (interrater). In an attempt to increase the rate of agreement, many of the parameters were either dichotomized into simply low‐ and high grade, or to a three‐tier system when more than three options in the original design. This increased the concurrence with 15.4% for the intrarater and with 23% for the interrater comparisons.<p><p> <i>Conclusion</i> - High agreement for histopathological parameters can be difficult to obtain on hematoxylin and eosin staining in scoring systems with many options. A simpler system might be more advantageous to achieve higher degree of reproducibility.en_US
dc.identifier.citationSteigen, Søland TM, Nginamau, Laurvik H, Costea, Johannessen AC, Jebsen PW, Bjerkli I, Uhlin-Hansen L, Hadler-Olsen ES. Grading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better?. Journal of Oral Pathology & Medicine. 2020;00:1-6en_US
dc.identifier.cristinIDFRIDAID 1785030
dc.identifier.doihttps://doi.org/10.1111/jop.12990
dc.identifier.issn0904-2512
dc.identifier.issn1600-0714
dc.identifier.urihttps://hdl.handle.net/10037/17330
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalJournal of Oral Pathology & Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleGrading of oral squamous cell carcinomas – Intra and interrater agreeability: Simpler is better?en_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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