dc.contributor.author | Nymo, Ståle Haugset | |
dc.contributor.author | Hartford, Marianne | |
dc.contributor.author | Ueland, Thor | |
dc.contributor.author | Yndestad, Arne | |
dc.contributor.author | Lorentzen, Erik | |
dc.contributor.author | Truvé, Katarina | |
dc.contributor.author | Karlsson, Thomas | |
dc.contributor.author | Ravn-Fischer, Annica | |
dc.contributor.author | Aukrust, Pål | |
dc.contributor.author | Caidahl, Kenneth | |
dc.date.accessioned | 2020-03-04T11:27:09Z | |
dc.date.available | 2020-03-04T11:27:09Z | |
dc.date.issued | 2018-03-08 | |
dc.description.abstract | <i>Background</i>
- Circulating neutrophil gelatinase-associated lipocalin (NGAL) concentration increases in cardiovascular disease, but the long-term prognostic value of NGAL concentration has not been evaluated in acute coronary syndrome (ACS). We examined the association between NGAL concentration and prognosis in patients with ACS after non-ST-elevation myocardial infarction (NSTEMI) or STEMI.<p><p>
<i>Methods and results</i>
- NGAL concentration was measured in blood from 1121 consecutive ACS patients (30% women, mean age 65 years) on the first morning after admission. After adjustment for 14 variables, NGAL concentration predicted long-term (median 167 months) mortality (hazard ratio [HR] 1.33, 95% confidence interval [CI] 1.10–1.61, <i>P</i> = 0.003) for quartile (q) 4 of NGAL concentration. NGAL concentrations also predicted long-term mortality (HR = 1.63, 95% CI 1.31–2.03, <i>P</i> < 0.001, N = 741) when adjusting for Global Registry of Acute Coronary Events (GRACE) score, left ventricular ejection fraction (LVEF), and pro-B-type natriuretic peptide (proBNP) and C-reactive protein (CRP) concentrations. With these adjustments, NGAL concentration predicted long-term mortality in NSTEMI patients (HR = 2.02, 95% CI 1.50–2.72, <i>P</i> < 0.001) but not in STEMI patients (HR = 1.32, 95% CI 0.95–1.83, <i>P</i> = 0.100). In all patients, the combination of NGAL concentration and GRACE score yielded an HR of 5.56 (95% CI 4.37–7.06, <i>P</i> < 0.001) for q4/q4 for both variables.<p><p>
<i>Conclusion</i>
- NGAL concentration in ACS is associated with long-term prognosis after adjustment for clinical confounders. Measuring circulating NGAL concentration may help to identify patients—particularly those with NSTEMI—needing closer follow-up after ACS. | en_US |
dc.description | Accepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0. </a> | en_US |
dc.identifier.citation | Nymo S, Hartford M, Ueland T, Yndestad A, Lorentzen E, Truvé, Karlsson T, Ravn-Fischer, Aukrust P, Caidahl K. Serum neutrophil gelatinase-associated lipocalin (NGAL) concentration is independently associated with mortality in patients with acute coronary syndrome. International Journal of Cardiology. 2018;262:79-84 | en_US |
dc.identifier.cristinID | FRIDAID 1592897 | |
dc.identifier.doi | 10.1016/j.ijcard.2018.03.028 | |
dc.identifier.issn | 0167-5273 | |
dc.identifier.issn | 1874-1754 | |
dc.identifier.uri | https://hdl.handle.net/10037/17599 | |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.journal | International Journal of Cardiology | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | © 2018 Published by Elsevier B.V. | en_US |
dc.subject | VDP::Medical disciplines: 700 | en_US |
dc.subject | VDP::Medisinske Fag: 700 | en_US |
dc.title | Serum neutrophil gelatinase-associated lipocalin (NGAL) concentration is independently associated with mortality in patients with acute coronary syndrome | en_US |
dc.type.version | acceptedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |