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dc.contributor.authorNymo, Ståle Haugset
dc.contributor.authorHartford, Marianne
dc.contributor.authorUeland, Thor
dc.contributor.authorYndestad, Arne
dc.contributor.authorLorentzen, Erik
dc.contributor.authorTruvé, Katarina
dc.contributor.authorKarlsson, Thomas
dc.contributor.authorRavn-Fischer, Annica
dc.contributor.authorAukrust, Pål
dc.contributor.authorCaidahl, Kenneth
dc.date.accessioned2020-03-04T11:27:09Z
dc.date.available2020-03-04T11:27:09Z
dc.date.issued2018-03-08
dc.description.abstract<i>Background</i> - Circulating neutrophil gelatinase-associated lipocalin (NGAL) concentration increases in cardiovascular disease, but the long-term prognostic value of NGAL concentration has not been evaluated in acute coronary syndrome (ACS). We examined the association between NGAL concentration and prognosis in patients with ACS after non-ST-elevation myocardial infarction (NSTEMI) or STEMI.<p><p> <i>Methods and results</i> - NGAL concentration was measured in blood from 1121 consecutive ACS patients (30% women, mean age 65 years) on the first morning after admission. After adjustment for 14 variables, NGAL concentration predicted long-term (median 167 months) mortality (hazard ratio [HR] 1.33, 95% confidence interval [CI] 1.10–1.61, <i>P</i> = 0.003) for quartile (q) 4 of NGAL concentration. NGAL concentrations also predicted long-term mortality (HR = 1.63, 95% CI 1.31–2.03, <i>P</i> < 0.001, N = 741) when adjusting for Global Registry of Acute Coronary Events (GRACE) score, left ventricular ejection fraction (LVEF), and pro-B-type natriuretic peptide (proBNP) and C-reactive protein (CRP) concentrations. With these adjustments, NGAL concentration predicted long-term mortality in NSTEMI patients (HR = 2.02, 95% CI 1.50–2.72, <i>P</i> < 0.001) but not in STEMI patients (HR = 1.32, 95% CI 0.95–1.83, <i>P</i> = 0.100). In all patients, the combination of NGAL concentration and GRACE score yielded an HR of 5.56 (95% CI 4.37–7.06, <i>P</i> < 0.001) for q4/q4 for both variables.<p><p> <i>Conclusion</i> - NGAL concentration in ACS is associated with long-term prognosis after adjustment for clinical confounders. Measuring circulating NGAL concentration may help to identify patients—particularly those with NSTEMI—needing closer follow-up after ACS.en_US
dc.descriptionAccepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0. </a>en_US
dc.identifier.citationNymo S, Hartford M, Ueland T, Yndestad A, Lorentzen E, Truvé, Karlsson T, Ravn-Fischer, Aukrust P, Caidahl K. Serum neutrophil gelatinase-associated lipocalin (NGAL) concentration is independently associated with mortality in patients with acute coronary syndrome. International Journal of Cardiology. 2018;262:79-84en_US
dc.identifier.cristinIDFRIDAID 1592897
dc.identifier.doi10.1016/j.ijcard.2018.03.028
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.urihttps://hdl.handle.net/10037/17599
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalInternational Journal of Cardiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2018 Published by Elsevier B.V.en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleSerum neutrophil gelatinase-associated lipocalin (NGAL) concentration is independently associated with mortality in patients with acute coronary syndromeen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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