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dc.contributor.authorEvensen, Line Holtet
dc.contributor.authorIsaksen, Trond
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2020-03-09T11:43:35Z
dc.date.available2020-03-09T11:43:35Z
dc.date.issued2019-08-25
dc.description.abstract<i>Background</i> - Cardiorespiratory fitness (CRF) is a strong predictor of future arterial cardiovascular disease and premature mortality. However, there are limited data on the association between CRF and the risk of incident venous thromboembolism (VTE).<p><p> <i>Objectives</i> - To investigate whether estimated CRF (eCRF) was associated with the risk of incident VTE in a cohort recruited from the general population.<p><p> <i>Methods</i> - Participants (<i>n</i> = 10 393) from the sixth survey of the Tromsø Study (2007—08) were included, and incident VTEs were recorded up to 31 December 2016. CRF was estimated in sex‐specific algorithms based on age, waist circumference, resting heart rate, and self‐reported physical activity. Hazard ratios (HRs) with 95% confidence intervals (CIs) of VTE according to categories of eCRF were estimated in Cox regression models adjusted for sex with age as timescale. The impact of weight status was evaluated in analyses stratified by weight category.<p><p> <i>Results</i> - There were 176 incident VTEs during follow‐up. Compared with individuals with eCRF < 85% of age‐predicted, those with eCRF of 85% to 100% and >100% of age‐predicted had 46% (HR 0.54; 95% CI 0.39‐0.77) and 67% (HR 0.33; 95% CI 0.20‐0.54) lower VTE risk, respectively. Compared with overweight/obese individuals with eCRF < 85% of age‐predicted, overweight/obese individuals with eCRF ≥ 85% had 50% (HR 0.50, 95% CI 0.35‐0.74) lower risk, and normal weight individuals with eCRF ≥ 85% had 55% (HR 0.45, 95% CI 0.30‐0.68) lower risk.<p><p> <i>Conclusions</i> - Higher eCRF was associated with lower risk of incident VTE. The association was independent of weight categories, suggesting that higher eCRF may modify the association between obesity and VTE.en_US
dc.descriptionThis is the peer reviewed version of the following article: Evensen, L. H., Isaksen, T., Brækkan, S. K. & Hansen, J.-B. (2019). Cardiorespiratory fitness and future risk of venous thromboembolism. <i>Journal of Thrombosis and Haemostasis, 17</i>(12), 2160-2168., which has been published in final form at <a href=https://doi.org/10.1111/jth.14619>https://doi.org/10.1111/jth.14619</a>. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.en_US
dc.identifier.citationEvensen L, Isaksen T, Brækkan SK, Hansen JB. Cardiorespiratory fitness and future risk of venous thromboembolism. Journal of Thrombosis and Haemostasis. 2019:1-9en_US
dc.identifier.cristinIDFRIDAID 1747059
dc.identifier.doi10.1111/jth.14619
dc.identifier.issn1538-7933
dc.identifier.issn1538-7836
dc.identifier.urihttps://hdl.handle.net/10037/17673
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.ispartofFinal version of this paper is part of:<p> <p>Evensen, L.H. (2020). Physical activity, cardiorespiratory fitness and venous thromboembolism. (Doctoral thesis). <a href=https://hdl.handle.net/10037/18072>https://hdl.handle.net/10037/18072.</a>
dc.relation.journalJournal of Thrombosis and Haemostasis
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2019 International Society on Thrombosis and Haemostasisen_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleCardiorespiratory fitness and future risk of venous thromboembolismen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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