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dc.contributor.authorScott, David
dc.contributor.authorJohansson, Jonas
dc.contributor.authorMcMillan, Lachlan
dc.contributor.authorEbeling, Peter R
dc.contributor.authorNordström, Anna Hava
dc.contributor.authorNordström, Peter
dc.date.accessioned2020-03-09T13:14:54Z
dc.date.available2020-03-09T13:14:54Z
dc.date.issued2018-12-08
dc.description.abstract<i>Background</i> - Lower skeletal muscle density, indicating greater infiltration of adipose tissue into muscles, is associated with higher fracture risk in older adults. We aimed to determine whether mid-calf muscle density is associated with falls risk and bone health in community-dwelling older adults.<p><p> <i>Methods</i> - 2214 community-dwelling men and women who participated in the Healthy Ageing Initiative (Sweden) study at age 70 were included in this analysis. Mid-calf muscle density (mg/cm<sup>3</sup>) at the proximal tibia, and volumetric bone mineral density (vBMD) and architecture at the distal and proximal tibia and radius, were assessed by peripheral quantitative computed tomography. Whole-body lean and fat mass, lumbar spine and total hip areal bone mineral density (aBMD) were assessed by dual-energy X-ray absorptiometry. Participants completed seven-day accelerometer measurements of physical activity intensity, and self-reported falls data were collected 6 and 12 months later.<p><p> <i>Results</i> - 302 (13.5%) participants reported a fall at the 6- or 12-month interview, and 29 (1.3%) reported a fall at both interviews. After adjustment for confounders, each standard deviation decrease in mid-calf muscle density was associated with a trend towards greater likelihood of experiencing a fall (OR 1.13; 95% CI 1.00, 1.29 per SD lower) and significantly greater likelihood of multiple falls (1.61; 1.16, 2.23). Higher muscle density was not associated with total hip aBMD, and was associated with lower lumbar spine aBMD (B = -0.003; 95% CI -0.005, -0.001 per mg/cm<sup>3</sup>) and higher proximal cortical vBMD (0.74; 0.20, 1.28) at the radius. At the tibia, muscle density was positively associated with distal total and trabecular vBMD, and proximal total and cortical vBMD, cortical thickness, cortical area and stress-strain index (all P < 0.05). Only moderate/vigorous (%) intensity physical activity, not sedentary time or light activity, was associated with higher mid-calf muscle density (0.086; 0.034, 0.138).<p><p> <i>Conclusions</i> - Lower mid-calf muscle density is independently associated with higher likelihood for multiple incident falls and appears to have localised negative effects on bone structure in older adults.en_US
dc.descriptionAccepted manuscript version, licensed <a href=http://creativecommons.org/licenses/by-nc-nd/4.0/> CC BY-NC-ND 4.0. </a>en_US
dc.identifier.citationScott D, Johansson J, McMillan, Ebeling, Nordström AH, Nordström P. Mid-calf skeletal muscle density and its associations with physical activity, bone health and incident 12-month falls in older adults: The Healthy Ageing Initiative. Bone. 2019;120en_US
dc.identifier.cristinIDFRIDAID 1690665
dc.identifier.doi10.1016/j.bone.2018.12.004
dc.identifier.issn8756-3282
dc.identifier.issn1873-2763
dc.identifier.urihttps://hdl.handle.net/10037/17678
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalBone
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2018 Elsevier Inc. All rights reserved.en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleMid-calf skeletal muscle density and its associations with physical activity, bone health and incident 12-month falls in older adults: The Healthy Ageing Initiativeen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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