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dc.contributor.authorVikberg, Sanna
dc.contributor.authorSörlén, Niklas
dc.contributor.authorBrandén, Jonas
dc.contributor.authorJohansson, Jonas
dc.contributor.authorNordström, Anna
dc.contributor.authorHult, Andreas
dc.contributor.authorNordström, Peter
dc.date.accessioned2020-03-11T10:29:09Z
dc.date.available2020-03-11T10:29:09Z
dc.date.issued2018-11-07
dc.description.abstract<i>Objective</i> - Sarcopenia has been defined as age-related loss of muscle mass and function. The aim of this randomized controlled trial was to examine the effects of a 10-week instructor-led resistance training program on functional strength and body composition in men and women aged 70 years with pre-sarcopenia.<p> <p><i>Design, Setting, and Participants</i> - Participants were randomized to either 10 weeks of a physical training regimen including optional nutritional supplementation (n = 36) or to a control group (n = 34) (ClinicalTrials.gov, no. NCT03297632). The main outcome was changes in the Short Physical Performance Battery (SPPB) score. Secondary outcomes included the Timed Up and Go test, chair sit-stand time, lean body mass, and fat mass.<p> <p><i>Results</i> - The intervention had no significant effect on SPPB in the total cohort (<i>P</i> = .18), when comparing changes in the intervention group with the control group. However, those given the intervention in the male subcohort increased 0.5 ± 0.4 (mean ± standard error for the difference) points in SPPB during follow-up (<i>P</i> = .02) compared to male controls. With respect to secondary outcomes, the intervention group decreased 0.9 ± 0.6 seconds in chair sit-stand time compared to controls (<i>P</i> = .01). Furthermore, the intervention resulted in significantly greater improvements for the training group than control group in all measures of body composition (<i>P</i> ≤ .01 for all). For example, lean body mass increased by a mean of 1147 ± 282 g (<i>P</i> < .001), and total fat mass decreased by a mean of 553 ± 225 g (<i>P</i> = .003), favoring the intervention group.<p> <p><i>Conclusion/Implications</i> - The main finding of this intervention study is that an easy-to-use, functional resistance training program was effective in maintaining functional strength and increasing muscle mass in older adults with pre-sarcopenia.en_US
dc.identifier.citationVikberg S, Nordström AH. Effects of Resistance Training on Functional Strength and Muscle Mass in 70-Year-Old Individuals With Pre-sarcopenia: A Randomized Controlled Trial.. Journal of the American Medical Directors Association. 2019en_US
dc.identifier.cristinIDFRIDAID 1750745
dc.identifier.issn1525-8610
dc.identifier.issn1538-9375
dc.identifier.urihttps://hdl.handle.net/10037/17714
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalJournal of the American Medical Directors Association
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleEffects of Resistance Training on Functional Strength and Muscle Mass in 70-Year-Old Individuals With Pre-sarcopenia: A Randomized Controlled Trialen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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