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dc.contributor.authorJang, Jieun
dc.contributor.authorCho, Eun-Jung
dc.contributor.authorHwang, Yunji
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorAhn, Choonghyun
dc.contributor.authorChoi, Jeoungbin
dc.contributor.authorChang, Soung-Hoon
dc.contributor.authorShin, Hai-Rim
dc.contributor.authorLim, Min Kyung
dc.contributor.authorYoo, Keun-Young
dc.contributor.authorPark, Sue K.
dc.date.accessioned2020-03-16T07:45:18Z
dc.date.available2020-03-16T07:45:18Z
dc.date.issued2018-11-21
dc.description.abstract<i>Purpose</i> - Few studies investigated roles of body mass index (BMI) on gastric cancer (GC) risk according to <i>Helicobacter pylori</i> infection status. This study was conducted to evaluate associations between BMI and GC risk with consideration of <i>H. pylori</i> infection information.<p><p> <i>Materials and Methods</i> - We performed a case-cohort study (n=2,458) that consists of a subcohort, (n=2,193 including 67 GC incident cases) randomly selected from the Korean Multicenter Cancer Cohort (KMCC) and 265 incident GC cases outside of the subcohort. <i>H. pylori</i> infection was assessed using an immunoblot assay. GC risk according to BMI was evaluated by calculating hazard ratios (HRs) and their 95% confidence intervals (95% CIs) using weighted Cox hazard regression model.<p><p> <i>Results</i> - Increased GC risk in lower BMI group (< 23 kg/m<sup>2</sup>) with marginal significance, (HR, 1.32; 95% CI, 0.98 to 1.77) compared to the reference group (BMI of 23-24.9 kg/m<sup>2</sup>) was observed. In the <i>H. pylori</i> non-infection, both lower (< 23 kg/m<sup>2</sup>) and higher BMI (≥ 25 kg/m<sup>2</sup>) showed non-significantly increased GC risk (HR, 10.82; 95% CI, 1.25 to 93.60 and HR, 11.33; 95% CI, 1.13 to 113.66, respectively). However, these U-shaped associations between BMI and GC risk were not observed in the group who had ever been infected by <i>H. pylori</i>.<p><p> <i>Conclusion</i> - This study suggests the U-shaped associations between BMI and GC risk, especially in subjects who had never been infected by <i>H. pylori</i>.en_US
dc.identifier.citationJang J, Cho, Hwang Y, Weiderpass E, Ahn, Choi, Chang S, Shin H, Lim, Yoo K, Park SK. Association between body mass index and gastric cancer risk according to effect modification by helicobacter pylori infection. Cancer research and treatment : official journal of Korean Cancer Association. 2019;51(3):1107-1116en_US
dc.identifier.cristinIDFRIDAID 1717633
dc.identifier.doi10.4143/crt.2018.182
dc.identifier.issn1598-2998
dc.identifier.issn2005-9256
dc.identifier.urihttps://hdl.handle.net/10037/17738
dc.language.isoengen_US
dc.publisherKorean Cancer Associationen_US
dc.relation.journalCancer research and treatment : official journal of Korean Cancer Association
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleAssociation between body mass index and gastric cancer risk according to effect modification by helicobacter pylori infectionen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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