Show simple item record

dc.contributor.authorBørvik, Trond
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.contributor.authorEvensen, Line
dc.contributor.authorBrodin, Ellen Elisabeth
dc.contributor.authorMorelli, Vania Maris
dc.contributor.authorMelbye, Hasse
dc.contributor.authorHansen, John-Bjarne
dc.date.accessioned2020-03-19T13:33:13Z
dc.date.available2020-03-19T13:33:13Z
dc.date.issued2019-12-30
dc.description.abstract<i>Background</i> - Previous studies have shown increased mortality in venous thromboembolism (VTE) patients with chronic obstructive pulmonary disease (COPD), but it is unknown to what extent the association is influenced by the severity of COPD and physical inactivity.<p> <p><i>Objectives</i> - This article investigates whether COPD, and stages of COPD, influenced the risk of mortality after a first episode of VTE when physical inactivity was taken into account.<p> <p><i>Methods</i> - Patients with a first lifetime VTE (<i>n</i> = 256) were recruited among individuals who participated and performed spirometry in the fifth (2001–2002) and sixth (2007–2008) surveys of the Tromsø Study (<i>n</i> = 9577). All-cause mortality was registered up to December 31, 2015.<p> <p><i>Results</i> - There were 123 deaths during a median of 2.9 years of follow-up. The overall mortality rate was 11.9 (95% confidence interval [CI] 10.0–14.2) per 100 person-years. The risk of death was twofold higher in COPD patients compared with those with normal airflow (hazard ratio [HR] 2.00, 95% CI 1.30–3.08) after multivariable adjustment. The risk of death increased with the severity of COPD. VTE patients with COPD stage III/IV had a fivefold increased risk of death (HR 5.20, 95% CI 2.65–10.2) compared with those without COPD, and 50% of these patients died within 3.5 months after the incident VTE event. Adjustment for physical inactivity had minor effect on the risk estimates.<p> <p><i>Conclusion</i> - VTE patients with COPD had increased risk of death, particularly patients with severe COPD. The detrimental effect of COPD on mortality in VTE patients was apparently explained by factors other than physical inactivity among patients with COPD.en_US
dc.identifier.citationBørvik T, Brækkan SK, Evensen L, Brodin EE, Morelli VM, Melbye H, Hansen JB. Chronic obstructive pulmonary Disease and risk of mortality in patients with venous thromboembolism - the Tromsø Study. Thrombosis and Haemostasis. 2019en_US
dc.identifier.cristinIDFRIDAID 1778520
dc.identifier.doi10.1055/s-0039-3400744
dc.identifier.issn0340-6245
dc.identifier.urihttps://hdl.handle.net/10037/17809
dc.language.isoengen_US
dc.publisherThieme Publishingen_US
dc.relation.journalThrombosis and Haemostasis
dc.rights.accessRightsopenAccessen_US
dc.rights.holder© 2020 Georg Thieme Verlag KGen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleChronic obstructive pulmonary Disease and risk of mortality in patients with venous thromboembolism - the Tromsø Studyen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record