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dc.contributor.authorMakrecka-Kuka, Marina
dc.contributor.authorLiepinsh, Edgars
dc.contributor.authorMurray, Andrew J.
dc.contributor.authorLemieux, Hélène
dc.contributor.authorDambrova, Maija
dc.contributor.authorTepp, Kersti
dc.contributor.authorPuurand, Marju
dc.contributor.authorKäämbre, Tuuli
dc.contributor.authorHan, Woo H.
dc.contributor.authorde Goede, Paul
dc.contributor.authorO'Brien, Katie A.
dc.contributor.authorTuran, Belma
dc.contributor.authorTuncay, Erkan
dc.contributor.authorOlgar, Yusuf
dc.contributor.authorRolo, Anabela P.
dc.contributor.authorPalmeira, Carlos M.
dc.contributor.authorBoardman, Neoma Tove
dc.contributor.authorWüst, Rob C.I.
dc.contributor.authorLarsen, Terje
dc.date.accessioned2020-03-26T12:25:39Z
dc.date.available2020-03-26T12:25:39Z
dc.date.issued2019-12-16
dc.description.abstractObesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is characterized by metabolic disturbances such as impaired glucose oxidation and an increased reliance on fatty acid (FA) oxidation. Mitochondrial dysfunction has often been associated with the altered metabolic function in the diabetic heart, and may result from FA‐induced lipotoxicity and uncoupling of oxidative phosphorylation. In this review, we address the metabolic changes in the diabetic heart, focusing on the loss of metabolic flexibility and cardiac mitochondrial function. We consider the alterations observed in mitochondrial substrate utilization, bioenergetics and dynamics, and highlight new areas of research which may improve our understanding of the cause and effect of cardiac mitochondrial dysfunction in diabetes. Finally, we explore how lifestyle (nutrition and exercise) and pharmacological interventions can prevent and treat metabolic and mitochondrial dysfunction in diabetes.en_US
dc.identifier.citationMakrecka-Kuka, Liepinsh, Murray, Lemieux H, Dambrova, Tepp, Puurand, Käämbre, Han, de Goede, O'Brien, Turan B, Tuncay E, Olgar, Rolo AP, Palmeira CM, Boardman N, Wüst, Larsen t. Altered mitochondrial metabolism in the insulin-resistant heart. Acta Physiologica. 2019;00:e13430:1-26en_US
dc.identifier.cristinIDFRIDAID 1782196
dc.identifier.doi10.1111/apha.13430
dc.identifier.issn1748-1708
dc.identifier.issn1748-1716
dc.identifier.urihttps://hdl.handle.net/10037/17874
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalActa Physiologica
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleAltered mitochondrial metabolism in the insulin-resistant hearten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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