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dc.contributor.authorRoaldsen, Marius Håke
dc.contributor.authorCiosek, Timothy Allan
dc.contributor.authorRichardsen, Elin
dc.contributor.authorAl-Saad, Samer
dc.contributor.authorPatel, Hitendra R.H.
dc.contributor.authorAarsæther, Erling Johan
dc.date.accessioned2020-04-01T09:03:54Z
dc.date.available2020-04-01T09:03:54Z
dc.date.issued2019-07-09
dc.description.abstract<i>Purpose</i>: To compare two clinically relevant anesthetic agents, i.e., isoflurane versus propofol with respect to protection of the kidney in a porcine renal ischemia reperfusion model. <p> <p><i>Materials and Methods</i>: 14 hybrid pigs were randomized to anesthesia with either isoflurane or propofol prior to laparoscopic surgery. Following anesthesia, the left kidney hilum was clamped for 60 min and the right kidney removed. After 48 h of reperfusion, urine was sampled for analysis of neutrophil gelatinase-associated lipocalin (NGAL), albumin, and creatinine. The left kidney was harvested for histologic scoring of injury. <p> <p><i>Results</i>: Histologic examination of renal injury revealed a statistically significant difference in favor of isoflurane on denuded basement membrane score (isoflurane group 1.58 ± 0.38 vs. propofol 2.42 ± 0.80, <i>p</i> = .026). Median (25–75 percentile) urinary albumin 3.4 g/L (2.25–7.48) vs. 8.9 g/L (3.73–13.8), (<i>p</i> = .041) and urinary albumin/creatinine ratio 1.17 (0.76–1.82) vs. 1.76 (1.63–5.99), (<i>p</i> = .026) were both significantly lower in the isoflurane group. Median (25–75 percentile) urinary NGAL was 167 (51–215) pg/ml in the isoflurane group compared with 362 (149–508) pg/ml in the propofol group (<i>p</i> = .093). <p> <p><i>Conclusion</i>: Isoflurane increases tolerance to renal ischemia reperfusion injury compared to propofol in this model.en_US
dc.descriptionThis is an Accepted Manuscript of an article published by Taylor & Francis in <i>Journal of investigate surgery</i> on 09 July 2019. Final version including figures, is available online: https://doi.org/10.1080/08941939.2019.1637038.en_US
dc.identifier.citationRoaldsen MH, Ciosek TA, Richardsen ER, Al-Saad SAS, Patel HR, Aarsæther EJ. Isoflurane increases tolerance to renal ischemia reperfusion injury compared to propofol: An experimental study in pigs. Journal of investigative surgery. 2019:1-8en_US
dc.identifier.cristinIDFRIDAID 1717675
dc.identifier.doi10.1080/08941939.2019.1637038
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.urihttps://hdl.handle.net/10037/17955
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.relation.journalJournal of investigative surgery
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright © 2019 Taylor & Francis Group, LLCen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.titleIsoflurane increases tolerance to renal ischemia reperfusion injury compared to propofol: An experimental study in pigsen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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