Vis enkel innførsel

dc.contributor.authorJansen, Kirsten
dc.contributor.authorMoreno, Sonia
dc.contributor.authorGarcia-Roves, Pablo M
dc.contributor.authorLarsen, Terje
dc.date.accessioned2020-05-05T06:06:15Z
dc.date.available2020-05-05T06:06:15Z
dc.date.issued2019-07-16
dc.description.abstractThe aim of this study was to find out whether dietary supplementation with Calanus oil (a novel marine oil) or infusion of exenatide (an incretin mimetic) could counteract obesity-induced alterations in myocardial metabolism and improve postischemic recovery of left ventricular (LV) function. Female C57bl/6J mice received high-fat diet (HFD, 45% energy from fat) for 12 wk followed by 8-wk feeding with nonsupplemented HFD, HFD supplemented with 2% Calanus oil, or HFD plus exenatide infusion (10 µg·kg−1·day−1). A lean control group was included, receiving normal chow throughout the whole period. Fatty acid and glucose oxidation was measured in ex vivo perfused hearts during baseline conditions, while LV function was assessed with an intraventricular fluid-filled balloon before and after 20 min of global ischemia. HFD-fed mice receiving Calanus oil or exenatide showed less intra-abdominal fat deposition than mice receiving nonsupplemented HFD. Both treatments prevented the HFD-induced decline in myocardial glucose oxidation. Somewhat surprising, recovery of LV function was apparently better in hearts from mice fed nonsupplemented HFD relative to hearts from mice fed normal chow. More importantly however, postischemic recovery of hearts from mice receiving HFD with Calanus oil was superior to that of mice receiving nonsupplemented HFD and mice receiving HFD with exenatide, as expressed by better pressure development, contractility, and relaxation properties. In summary, dietary Calanus oil and administration of exenatide counteracted obesity-induced derangements of myocardial metabolism. Calanus oil also protected the heart from ischemia, which could have implications for the prevention of obesity-related cardiac disease.en_US
dc.identifier.citationJansen, K; Moreno, S.; Garcia-Roves, P.M.; Larsen, T.(2019) Dietary calanus oil recovers metabolic flexibility and rescues postischemic cardiac function in obese female mice. <i>American Journal of Physiology. Heart and Circulatory Physiology, 317,</i>(2), H290-H299en_US
dc.identifier.cristinIDFRIDAID 1728507
dc.identifier.doi10.1152/ajpheart.00191.2019
dc.identifier.issn0363-6135
dc.identifier.issn1522-1539
dc.identifier.urihttps://hdl.handle.net/10037/18212
dc.language.isoengen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.ispartofJansen, K.M. (2021). Modulation of Cardiometabolic Health by Dietary Supplementation with Calanus oil. (Doctoral thesis). <a href=https://hdl.handle.net/10037/22254>https://hdl.handle.net/10037/22254</a>.
dc.relation.journalAmerican Journal of Physiology. Heart and Circulatory Physiology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright © 2019 the American Physiological Societyen_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800en_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800en_US
dc.titleDietary calanus oil recovers metabolic flexibility and rescues postischemic cardiac function in obese female miceen_US
dc.type.versionacceptedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel