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dc.contributor.authorEinrem, Rune F.
dc.contributor.authorAlemayehu, Abraham
dc.contributor.authorBorisov, Sergey M.
dc.contributor.authorGhosh, Abhik
dc.contributor.authorGederaas, Odrun Arna
dc.date.accessioned2020-06-02T11:24:25Z
dc.date.available2020-06-02T11:24:25Z
dc.date.issued2020-04-27
dc.description.abstractA set of rhenium(V)-oxo <i>meso</i>-triarylcorroles bearing ester and carboxylic acid functionalities were synthesized with a view to determining their potential for photodynamic therapy. Toward this end, we measured their near-IR phosphorescence and their ability to sensitize singlet oxygen formation. The two esters studied, Re<sup>V</sup>O 5,10,15-tris(<i>meta</i>-carbomethoxyphenyl)corrole and Re<sup>V</sup>O 5,10,15-tris(<i>para</i>-carbomethoxyphenyl)corrole, were found to exhibit phosphorescence quantum yields of around 1% and fairly long phosphorescence lifetimes of about 60 μs in toluene. The corresponding carboxylic acids, which were examined in ethanolic/aqueous media, in contrast, showed much lower phosphorescence quantum yields on the order of 0.01% and somewhat shorter phosphorescent lifetimes. The quantum yields for singlet oxygen formation, on the other hand, turned out to be equally high (0.72 ± 0.02) for the esters and corresponding carboxylic acids. For the two carboxylic acids, we also carried out photocytotoxicity measurements on rat bladder cancer cells (AY27) and human colon carcinoma cells (WiDr). Cell viability measurements (MTT assays) indicated 50% cell death (LD<sub>50</sub>) for AY27 cells upon 5 min of blue light exposure with the meta carboxylic acid and upon 7 min of exposure with the para carboxylic acid; complete cell death resulted after 20 min for both compounds. The WiDr cells proved less sensitive, and LD<sub>50</sub> values were reached after 8 and 12 min illumination with the meta and para carboxylic acids, respectively.en_US
dc.identifier.citationEinrem R, Ghosh A, Alemayehu A, Borisov SM, Gederaas OA. Amphiphilic Rhenium-Oxo Corroles as a New Class of Sensitizers for Photodynamic Therapy. ACS Omega. 2020(5):10596-10601en_US
dc.identifier.cristinIDFRIDAID 1813353
dc.identifier.doihttps://doi.org/10.1021/acsomega.0c01090
dc.identifier.issn2470-1343
dc.identifier.urihttps://hdl.handle.net/10037/18426
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofEinrem, R.F. (2023). New Building Blocks for Cancer Phototherapeutics: 5d Metallocorroles. (Doctoral thesis). <a href=https://hdl.handle.net/10037/28538>https://hdl.handle.net/10037/28538</a>.
dc.relation.journalACS Omega
dc.relation.projectIDNorges forskningsråd: 262229en_US
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/NANO2021/262229/Norway/Metallocorroles for photodynamic therapy and bioimaging//en_US
dc.relation.urihttps://pubs.acs.org/doi/pdf/10.1021/acsomega.0c01090
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright © 2020 American Chemical Societyen_US
dc.subjectFotokjemi / Photochemistryen_US
dc.subjectKjemi / Chemistryen_US
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440en_US
dc.titleAmphiphilic Rhenium-Oxo Corroles as a New Class of Sensitizers for Photodynamic Therapyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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