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dc.contributor.authorImahori, Yume
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorMorgan, Katy E.
dc.contributor.authorFrost, Chris
dc.contributor.authorHughes, Alun D.
dc.contributor.authorHopstock, Laila Arnesdatter
dc.contributor.authorJohnsen, Stein Harald
dc.contributor.authorEmaus, Nina
dc.contributor.authorLeon, David Adrew
dc.date.accessioned2020-06-11T07:29:50Z
dc.date.available2020-06-11T07:29:50Z
dc.date.issued2020-03-17
dc.description.abstract<i>Background</i> - Few reports are available on the contribution of general and abdominal obesity to the progression of carotid atherosclerosis in late adulthood. This study investigated the impact of four simple anthropometric measures of general and abdominal obesity on the progression of carotid atherosclerosis and the extent to which the association between adiposity and the progression of plaque burden is mediated by cardiometabolic markers.<p><p> <i>Methods</i> - Four thousand three hundred forty-five adults (median age 60) from the population-based Tromsø Study were followed over 7 years from the first carotid ultrasound screening to the next. The progression of carotid atherosclerosis was measured in three ways: incidence of plaques in previously plaque-free participants; change in the number of plaques; and total plaque area (TPA). We used generalised linear models to investigate the association between each adiposity measure – body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) – and each outcome. Models were adjusted for potential confounders (age, sex, smoking, education, physical activity). The pathways through which any associations observed might operate were investigated by further adjusting for cardiometabolic mediators (systolic blood pressure, cholesterol, and HbA1c).<p><p> <i>Results</i> - There was little evidence that adiposity was related to the formation of new plaques during follow-up. However, abdominal adiposity was associated with TPA progression. WHtR showed the largest effect size (mean change in TPA per one standard deviation (SD) increase in WHtR of 0.665 mm<sup>2</sup>, 95% confidence interval 0.198, 1.133) while BMI showed the smallest. Effect sizes were substantially reduced after the adjustment for potential mediators.<p><p> <i>Conclusions</i> - Abdominal obesity indirectly measured with WC seems more strongly associated with the progression of TPA than general obesity. These associations appear to be largely mediated by known cardiometabolic markers.en_US
dc.identifier.citationImahori Y, Mathiesen EB, Morgan KE, Frost C, Hughes AD, Hopstock LA, Johnsen SH, Emaus N, Leon DA. The association between anthropometric measures of adiposity and the progression of carotid atherosclerosis. BMC Cardiovascular Disorders. 2020;20:138:1-10en_US
dc.identifier.cristinIDFRIDAID 1808105
dc.identifier.doi10.1186/s12872-020-01417-0
dc.identifier.issn1471-2261
dc.identifier.urihttps://hdl.handle.net/10037/18511
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalBMC Cardiovascular Disorders
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleThe association between anthropometric measures of adiposity and the progression of carotid atherosclerosisen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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