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dc.contributor.authorBjerkli, Inger-Heidi
dc.contributor.authorJetlund, Olav
dc.contributor.authorKarevold, Gunnhild
dc.contributor.authorKarlsdottir, Åsa
dc.contributor.authorJaatun, Ellen A. Andreassen
dc.contributor.authorUhlin-Hansen, Lars
dc.contributor.authorRikardsen, Oddveig G
dc.contributor.authorHadler-Olsen, Elin Synnøve
dc.contributor.authorSteigen, Sonja Eriksson
dc.date.accessioned2020-06-15T11:45:08Z
dc.date.available2020-06-15T11:45:08Z
dc.date.issued2020-01-16
dc.description.abstract<i>Objectives</i> - Incidence of oral cavity squamous cell carcinomas is rising worldwide, and population characterization is important to follow for future trends. The aim of this retrospective study was to present a large cohort of primary oral cavity squamous cell carcinoma from all four health regions of Norway, with descriptive clinicopathological characteristics and five-year survival outcomes.<p><p> <i>Materials and methods</i> - Patients diagnosed with primary treatment-naïve oral cavity squamous cell carcinomas at all four university hospitals in Norway between 2005–2009 were retrospectively included in this study. Clinicopathological data from the electronic health records were compared to survival data.<p><p> <i>Results</i> - A total of 535 patients with primary treatment-naïve oral cavity squamous cell carcinomas were identified. The median survival follow-up time was 48 months (range 0–125 months) after treatment. The median five-year overall survival was found to be 47%. Median five-year disease-specific survival was 52%, ranging from 80% for stage I to 33% for stage IV patients. For patients given treatment with curative intent, the overall survival was found to be 56% and disease-specific survival 62%. Median age at diagnosis was 67 years (range 24–101 years), 64 years for men and 72 years for women. The male: female ratio was 1.2. No gender difference was found in neither tumor status (p = 0.180) nor node status (p = 0.266), but both factors influenced significantly on survival (p<0.001 for both).<p><p> <i>Conclusions</i> - We present a large cohort of primary treatment-naïve oral cavity squamous cell carcinomas in Norway. Five-year disease-specific survival was 52%, and patients eligible for curative treatment had a five-year disease-specific survival up to 62%.en_US
dc.identifier.citationBjerkli I, Jetlund O, Karevold G, Karlsdottir Å, Jaatun EAA, Uhlin-Hansen L, Rikardsen O, Hadler-Olsen ES, Steigen SE. Characteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective study. PLoS Medicine. 2020en_US
dc.identifier.cristinIDFRIDAID 1809365
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0227738
dc.identifier.issn1549-1277
dc.identifier.issn1549-1676
dc.identifier.urihttps://hdl.handle.net/10037/18542
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofBjerkli, I.H. (2020). Prognostic indicators of survival for patients with oral cavity squamous cell carcinoma in Norway. Outcomes in a retrospective, multicenter cohort, with special focus on oral tongue squamous cell carcinoma, 2005-2009. (Doctoral thesis). <a href=https://hdl.handle.net/10037/19390>https://hdl.handle.net/10037/19390</a>
dc.relation.journalPLoS Medicine
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.titleCharacteristics and prognosis of primary treatment-naïve oral cavity squamous cell carcinoma in Norway, a descriptive retrospective studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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