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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

dc.contributor.authorGalluzzi, Lorenzo
dc.contributor.authorVitale, Ilio
dc.contributor.authorWarren, Sarah
dc.contributor.authorAdjemian, Sandy
dc.contributor.authorAgostinis, Patrizia
dc.contributor.authorMartinez, Aitziber Burque
dc.contributor.authorChan, Timothy A.
dc.contributor.authorCoukos, George
dc.contributor.authorDemaria, Sandra
dc.contributor.authorDeutsch, Eric
dc.contributor.authorDraganov, Dobrin
dc.contributor.authorEdelson, Richard L
dc.contributor.authorFormenti, Silvia C.
dc.contributor.authorFucikova, Jitka
dc.contributor.authorGabriele, Lucia
dc.contributor.authorGaipl, Udo S.
dc.contributor.authorGameiro, Sofia R.
dc.contributor.authorGarg, Abhishek D.
dc.contributor.authorGolden, Encouse
dc.contributor.authorHan, Jian
dc.contributor.authorHarrington, Kevin J.
dc.contributor.authorHemminki, Akseli
dc.contributor.authorHodge, James W.
dc.contributor.authorHossain, Dewan Md Sakib
dc.contributor.authorIllidge, Tim
dc.contributor.authorKarin, Michael
dc.contributor.authorKaufman, Howard L.
dc.contributor.authorKepp, Oliver
dc.contributor.authorKroemer, Guido
dc.contributor.authorLasarte, Juan Jose
dc.contributor.authorLoi, Sherene
dc.contributor.authorLotze, Michael T.
dc.contributor.authorManic, Gwenola
dc.contributor.authorMerghoub, Taha
dc.contributor.authorMelcher, Alan A.
dc.contributor.authorMossman, Karen L.
dc.contributor.authorProsper, Felipe
dc.contributor.authorRekdal, Øystein
dc.contributor.authorRescigno, Maria
dc.contributor.authorRiganti, Chiara
dc.contributor.authorSistigu, Antonella
dc.contributor.authorSmyth, Mark J.
dc.contributor.authorSpisek, Radek
dc.contributor.authorStagg, John
dc.contributor.authorStrauss, Bryan E.
dc.contributor.authorTang, Daolin
dc.contributor.authorTatsuno, Kazuki
dc.contributor.authorvan Gool, Stefaan W.
dc.contributor.authorVandenabeele, Peter
dc.contributor.authorYamazaki, Takahiro
dc.contributor.authorZamarin, Dmitriy
dc.contributor.authorZitvogel, Laurence
dc.contributor.authorCesano, Alessandra
dc.contributor.authorMarincola, Francesco M.
dc.date.accessioned2020-06-17T11:09:23Z
dc.date.available2020-06-17T11:09:23Z
dc.date.issued2020-03-09
dc.description.abstractCells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.en_US
dc.identifier.citationGalluzzi L, Vitale I, Warren, Adjemian S, Agostinis P, Martinez, Chan, Coukos G, Demaria, Deutsch E, Draganov, Edelson, Formenti, Fucikova, Gabriele, Gaipl, Gameiro, Garg, Golden, Han J, Harrington KJ, Hemminki, Hodge, Hossain, Illidge, Karin, Kaufman, Kepp O, Kroemer G, Lasarte, Loi S, Lotze, Manic, Merghoub, Melcher, Mossman, Prosper F, Rekdal Ø, Rescigno, Riganti, Sistigu, Smyth MJ, Spisek, Stagg J, Strauss BE, Tang D, Tatsuno, van Gool, Vandenabeele P, Yamazaki T, Zamarin, Zitvogel L, Cesano, Marincola. Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. Journal for ImmunoTherapy of Cancer (JITC). 2020;8:e000337:1-21en_US
dc.identifier.cristinIDFRIDAID 1807632
dc.identifier.doi10.1136/jitc-2019-000337
dc.identifier.issn2051-1426
dc.identifier.urihttps://hdl.handle.net/10037/18585
dc.language.isoengen_US
dc.publisherBMJen_US
dc.relation.journalJournal for ImmunoTherapy of Cancer (JITC)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Communicable diseases: 776en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Infeksjonsmedisin: 776en_US
dc.titleConsensus guidelines for the definition, detection and interpretation of immunogenic cell deathen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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