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dc.contributor.authorGevorgyan, Ashot
dc.contributor.authorHopmann, Kathrin Helen
dc.contributor.authorBayer, Annette
dc.date.accessioned2020-06-24T10:37:31Z
dc.date.available2020-06-24T10:37:31Z
dc.date.issued2020-01-31
dc.description.abstractA formal C−H carboxylation of unactivated arenes using CO<sub>2</sub> in green solvents is described. The present strategy combines a sterically controlled Ir‐catalyzed C−H borylation followed by a Cu‐catalyzed carboxylation of the in situ generated organoboronates. The reaction is highly regioselective for the C−H carboxylation of 1,3‐disubstituted and 1,2,3‐trisubstituted benzenes, 1,2‐ or 1,4‐symmetrically substituted benzenes, fluorinated benzenes and different heterocycles. The developed methodology was applied to the late‐stage C−H carboxylation of commercial drugs and ligands.en_US
dc.identifier.citationGevorgyan A, Hopmann KH, Bayer A. Formal C-H carboxylation of unactivated arenes with carbon dioxide. Chemistry - A European Journal. 2020en_US
dc.identifier.cristinIDFRIDAID 1788743
dc.identifier.doi10.1002/chem.202000515
dc.identifier.issn0947-6539
dc.identifier.issn1521-3765
dc.identifier.urihttps://hdl.handle.net/10037/18646
dc.language.isoengen_US
dc.publisherEuropean Chemical Societies Publishingen_US
dc.relation.journalChemistry - A European Journal
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Chemistry: 440en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Kjemi: 440en_US
dc.titleFormal C-H carboxylation of unactivated arenes with carbon dioxideen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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