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dc.contributor.authorHansen, Elisabeth
dc.contributor.authorHuber, Nikolaus
dc.contributor.authorBustnes, Jan Ove
dc.contributor.authorHerzke, Dorte
dc.contributor.authorBårdsen, Bård-Jørgen
dc.contributor.authorEulaers, Igor
dc.contributor.authorJohnsen, Trond Vidar
dc.contributor.authorBourgeon, Sophie
dc.date.accessioned2020-06-24T11:15:10Z
dc.date.available2020-06-24T11:15:10Z
dc.date.issued2020-05
dc.description.abstractApex predators are characterized by high levels of biomagnifying organohalogenated contaminants (OHCs) which have been found to induce detrimental health effects in wildlife, such as immune system impairment. The leukocyte coping capacity (LCC) assay is a functional real-time measure of an innate immune response essential in pathogen resistance, known as the respiratory burst. The current study suggests the novel use of this tool to test whether OHCs impair the innate immune system of a sentinel top predator, the white-tailed eagle (Haliaeetus albicilla; WTE). The LCC analysis was performed in the field on WTE nestlings (n = 84) from northern Norway over two breeding seasons. Poly- and perfluoroalkyl substances (PFAS) dominated the total OHC load, surpassing the levels of legacy organochlorines. In addition, we detected significant negative correlations between concentrations of all polychlorinated biphenyls, p,p′-dichlorodiphenyldichloroethylene, perfluorohexane sulfonic acid and long-chain perfluorocarboxylic acids and the LCC of WTE nestlings. Based on our current findings reflecting a potential negative effect of both emerging and legacy OHCs on innate immune capacity, we suggest LCC to be a relevant and accessible test expanding the ecotoxicological toolbox to assess sub-lethal effects of OHCs in apex avian wildlife.en_US
dc.identifier.citationHansen, E.; Huber, N., Bustnes, J.O., Herzke, D., Bårdsen, B.J., Eulaers, I., Johnsen, T.V., Bourgeon, S. (2020) A novel use of the leukocyte coping capacity assay to assess the immunomodulatory effects of organohalogenated contaminants in avian wildlife. <i>Environment International,142 </i>. https://doi.org/10.1016/j.envint.2020.105861en_US
dc.identifier.cristinIDFRIDAID 1816244
dc.identifier.doihttps://doi.org/10.1016/j.envint.2020.105861
dc.identifier.issn0160-4120
dc.identifier.issn1873-6750
dc.identifier.urihttps://hdl.handle.net/10037/18649
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalEnvironment International
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480en_US
dc.titleA novel use of the leukocyte coping capacity assay to assess the immunomodulatory effects of organohalogenated contaminants in avian wildlifeen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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