Moodie, Lindon; Zuzek, Monika; Frangez, Robert; Andersen, Jeanette hammer; Hansen, Espen; Olsen, Elisabeth Klungerbo; Cergolj, Marija; Sepcic, Kristina; Hanssen, Kine Østnes; Svenson, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-09)
The marine secondary metabolite stryphnusin (1) was isolated from the boreal sponge Stryphnus fortis, collected off the Norwegian coast. Given its resemblance to other natural acetylcholinesterase antagonists, it was evaluated against electric eel acetylcholinesterase and displayed inhibitory activity. A library of twelve synthetic phenethylamine analogs, 2a–7a and 2b–7b, containing tertiary and ...