Blar i forfatter Artikler, rapporter og annet (kjemi) "Rahman, Ataur"

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    • A concise SAR-analysis of antimicrobial cationic amphipathic barbiturates for an improved activity-toxicity profile 

      Langer, Manuel K; Rahman, Ataur; Dey, Hymonti; Anderssen, Trude; Zilioli, Francesco; Haug, Tor; Blencke, Hans-Matti; Stensvåg, Klara; Strøm, Morten B.; Bayer, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-05)
      An amphipathic barbiturate mimic of the marine eusynstyelamides is reported as a promising class of antimicrobial agents. We hereby report a detailed analysis of the structure-activity relationship for cationic amphipathic N,N′ -dialkylated-5,5-disubstituted barbiturates. The influence of various cationic groups, hydrocarbon linkers and lipophilic side chains on the compounds’ antimicrobial potency ...

    • Investigation of tetrasubstituted heterocycles reveals hydantoins as a promising scaffold for development of novel antimicrobials with membranolytic properties 

      Langer, Manuel K; Rahman, Ataur; Dey, Hymonti; Anderssen, Trude; Blencke, Hans-Matti; Haug, Tor; Stensvåg, Klara; Strøm, Morten B.; Bayer, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-24)
      Mimics of antimicrobial peptides (AMPs) have been proposed as a promising class of antimicrobial agents. We report the analysis of five tetrasubstituted, cationic, amphipathic heterocycles as potential AMP mimics. The analysis showed that the heterocyclic scaffold had a strong influence on the haemolytic activity of the compounds, and the hydantoin scaffold was identified as a promising template for ...